Ge Yazhong, Qiu Huamai, Zheng Jianxian
School of Food Science and Engineering, South China University of Technology, Guangzhou, Guangdong 510640, China.
Food Chem X. 2022 Sep 12;15:100443. doi: 10.1016/j.fochx.2022.100443. eCollection 2022 Oct 30.
To investigate the effects of () on hyperlipidemic mice, polysaccharide (HLP) was prepared from by hot water extraction and alcohol precipitation. HLP was primarily contained glucose, rhamnose, galactose and mannose, with an average molecular weight of 7.34 × 10 Da. It was a complex and irregular network with a few pores by scanning electron microscopy. Meanwhile, oral administration of HLP at 60 mg/kg decreased levels of total cholesterol, triglycerides, and low-density lipoprotein cholesterol in serum while increased that of high-density lipoprotein cholesterol in high fat diet (HFD) mice. Furthermore, HLP significantly reversed the serum aspartate transaminase, alanine transaminase, and free fatty acid levels in HFD mice. Moreover, HLP treatment markedly regulated the mRNA levels of PPAR-α, ACS, and CPT-1α compared to the model group. Thus, these findings support that the supplement of polysaccharide is a novel complementary alternative strategy for management of hyperlipidemia.
为研究（）对高脂血症小鼠的影响，采用热水提取和乙醇沉淀法从（）中制备了多糖（HLP）。HLP主要含有葡萄糖、鼠李糖、半乳糖和甘露糖，平均分子量为7.34×10 Da。通过扫描电子显微镜观察，它是一个具有少量孔隙的复杂不规则网络。同时，高脂饮食（HFD）小鼠口服60 mg/kg的HLP可降低血清中总胆固醇、甘油三酯和低密度脂蛋白胆固醇水平，同时提高高密度脂蛋白胆固醇水平。此外，HLP显著逆转了HFD小鼠血清中天冬氨酸转氨酶、丙氨酸转氨酶和游离脂肪酸水平。而且，与模型组相比，HLP处理显著调节了PPAR-α、ACS和CPT-1α的mRNA水平。因此，这些研究结果支持补充（）多糖是一种治疗高脂血症的新型补充替代策略。
