Evangelatos Nikolaos, Bauer Pia, Reumann Matthias, Satyamoorthy Kapaettu, Lehrach Hans, Brand Angela
Intensive Care Medicine Unit, Department of Respiratory Medicine, Allergology and Sleep Medicine, Paracelsus Medical University, Nuremberg, Germany.
UNU-MERIT (Maastricht Economic and Social Research Institute on Innovation and Technology), Maastricht University, Maastricht, the Netherlands.
Public Health Genomics. 2017;20(5):274-285. doi: 10.1159/000486362. Epub 2018 Jan 19.
Sepsis, with its often devastating consequences for patients and their families, remains a major public health concern that poses an increasing financial burden. Early resuscitation together with the elucidation of the biological pathways and pathophysiological mechanisms with the use of "-omics" technologies have started changing the clinical and research landscape in sepsis. Metabolomics (i.e., the study of the metabolome), an "-omics" technology further down in the "-omics" cascade between the genome and the phenome, could be particularly fruitful in sepsis research with the potential to alter the clinical practice. Apart from its benefit for the individual patient, metabolomics has an impact on public health that extends beyond its applications in medicine. In this review, we present recent developments in metabolomics research in sepsis, with a focus on pneumonia, and we discuss the impact of metabolomics on public health, with a focus on free/libre open source software.
脓毒症对患者及其家庭往往造成毁灭性后果，仍然是一个重大的公共卫生问题，且带来日益加重的经济负担。早期复苏以及运用“组学”技术阐明生物学途径和病理生理机制，已开始改变脓毒症的临床和研究格局。代谢组学（即对代谢组的研究）是处于基因组和表型组之间“组学”层级中更下游的一种“组学”技术，在脓毒症研究中可能成果丰硕，具有改变临床实践的潜力。除了对个体患者有益外，代谢组学对公共卫生的影响超出了其在医学中的应用范畴。在本综述中，我们介绍脓毒症代谢组学研究的最新进展，重点关注肺炎，并讨论代谢组学对公共卫生的影响，重点关注自由/开源软件。
