Department of Pharmacology, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia.
Department of Pharmacy Practice, College of Pharmacy, AlMaarefa University, Ad Diriyah, 13713, Saudi Arabia.
Mol Cell Biochem. 2022 Sep;477(9):2203-2211. doi: 10.1007/s11010-022-04432-1. Epub 2022 Apr 22.
In individuals with sepsis-related neurodegenerative illness, sleep and circadian rhythm disturbance are common. The alteration in genomic expression linked with the immune-directed oxidative stress-inflammatory axis is thought to cause these individuals' abnormal sleep. On the other hand, sleep is linked to normal brain activity through common neurotransmitter systems and regulatory mechanisms. Ailments (ranging from cognitive to metabolic abnormalities) are seldom related to aberrant sleep that is made worse by sleep disturbance, which throws off the body's sleep-wake cycle. PubMed/Springer link /Public library of science/ScienceDirect/ Mendeley/Medline and Google Scholar were used to find possibly relevant studies. For the literature search, many keywords were considered, both individually and in combination. 'Sepsis,' 'Epidemiology of sepsis,' 'Sepsis-related hyper inflammation,' 'Relationship of sepsis-associated clock gene expression and relationship of inflammation with the reprogramming of genetic alterations' were some of the key terms utilized in the literature search. Our main objective is to understand better how traumatic infections during sepsis affect CNS processes, particularly sleep, by investigating the pathobiology of circadian reprogramming associated with immune-directed oxidative stress-inflammatory pathway responsive gene expression and sleep-wake behaviour in this study.
在与脓毒症相关的神经退行性疾病患者中，睡眠和昼夜节律紊乱很常见。人们认为，与免疫定向氧化应激-炎症轴相关的基因组表达改变导致了这些患者的睡眠异常。另一方面，睡眠通过共同的神经递质系统和调节机制与正常大脑活动有关。疾病（从认知到代谢异常）很少与睡眠异常有关，而睡眠障碍会使睡眠异常恶化，从而打乱身体的睡眠-觉醒周期。使用 PubMed/Springer 链接/公共科学图书馆/科学直接/Mendeley/Medline 和 Google Scholar 查找可能相关的研究。在文献检索中，考虑了许多单独和组合的关键字。在文献检索中使用了一些关键词，包括“脓毒症”、“脓毒症的流行病学”、“与脓毒症相关的过度炎症”、“与炎症相关的脓毒症相关时钟基因表达的关系与遗传改变的重编程的关系”。我们的主要目标是通过研究与免疫定向氧化应激-炎症途径反应基因表达和睡眠-觉醒行为相关的昼夜节律重编程的病理生物学，更好地了解脓毒症期间创伤性感染如何影响中枢神经系统过程，特别是睡眠。
