Uko G, Dawkins R L, Kay P, Christiansen F T, Hollingsworth P N
Clin Exp Immunol. 1985 Nov;62(2):329-36.
Erythrocytes from 30 patients suffering from systemic lupus erythematosus (SLE) were tested for CR1 activity by an immune adherence haemagglutination technique. Defective CR1 activity (CR1D) was found in 11 (37%) of the patients on initial testing. On repeat testings, however, CR1 activity often varied from time to time and was shown to be inversely related to serum anti-DNA binding and apparent complement activation in vivo. Two of the 19 patients with normal CR1 activity acquired CR1D during the study. One patient with previously defective CR1 attained normal activity in the course of the study. The increased occurrence of CR1D in patients with SLE is largely or wholly acquired rather than genetically determined.
采用免疫黏附血凝技术对30例系统性红斑狼疮（SLE）患者的红细胞进行CR1活性检测。初次检测时，11例（37%）患者发现存在CR1活性缺陷（CR1D）。然而，在重复检测时，CR1活性常常随时间变化，且显示出与血清抗DNA结合及体内明显的补体激活呈负相关。19例CR1活性正常的患者中有2例在研究期间出现了CR1D。1例先前CR1有缺陷的患者在研究过程中CR1活性恢复正常。SLE患者中CR1D发生率增加很大程度上或完全是后天获得的，而非由遗传决定。
