Rosso Fernando, Pineda Juan C, Sanz Ana M, Cedano Jorge A, Caicedo Luis A
Fundación Valle del Lili, Departamento de Medicina Interna - Enfermedades Infecciosas, Cali, Colombia; Universidad Icesi, Facultad de Ciencias de la Salud, Cali, Colombia; Fundación Valle del Lili, Centro de Investigaciones Clínicas, Cali, Colombia.
Universidad Icesi, Facultad de Ciencias de la Salud, Cali, Colombia.
Braz J Infect Dis. 2018 Jan-Feb;22(1):63-69. doi: 10.1016/j.bjid.2018.01.001. Epub 2018 Jan 19.
Dengue fever is a vector-transmitted viral infection. Non-vectorial forms of transmission can occur through organ transplantation. We reviewed medical records of donors and recipients with suspected dengue in the first post-transplant week. We used serologic and molecular analysis to confirm the infection. Herein, we describe four cases of dengue virus transmission through solid organ transplantation. The recipients had positive serology and RT-PCR. Infection in donors was detected through serology. All cases presented with fever within the first week after transplantation. There were no fatal cases. After these cases, we implemented dengue screening with NS1 antigen detection in donors during dengue outbreaks, and no new cases were detected. In the literature review, additional cases had been published through August 2017. Transmission of Dengue virus can occur through organ donation. In endemic regions, it is important to suspect and screen for dengue in febrile and thrombocytopenic recipients in the postoperative period.
登革热是一种由媒介传播的病毒感染。非媒介传播形式可通过器官移植发生。我们回顾了移植后第一周疑似登革热的供体和受体的病历。我们使用血清学和分子分析来确诊感染。在此，我们描述了4例通过实体器官移植传播登革病毒的病例。受体的血清学和逆转录聚合酶链反应（RT-PCR）呈阳性。通过血清学检测到供体感染。所有病例在移植后第一周内出现发热。无死亡病例。在这些病例之后，我们在登革热暴发期间对供体进行NS1抗原检测的登革热筛查，未检测到新病例。在文献综述中，截至2017年8月已发表了其他病例。登革病毒可通过器官捐赠传播。在流行地区，术后对发热和血小板减少的受体怀疑并筛查登革热很重要。
