Deshmukh Sunil K, Prakash Ved, Ranjan Nihar
TERI-Deakin Nano Biotechnology Centre, The Energy and Resources Institute, New Delhi, India.
Department of Biotechnology, Motilal Nehru National Institute of Technology, Allahabad, India.
Front Microbiol. 2018 Jan 5;8:2536. doi: 10.3389/fmicb.2017.02536. eCollection 2017.
Metabolites from marine fungi have hogged the limelight in drug discovery because of their promise as therapeutic agents. A number of metabolites related to marine fungi have been discovered from various sources which are known to possess a range of activities as antibacterial, antiviral and anticancer agents. Although, over a thousand marine fungi based metabolites have already been reported, none of them have reached the market yet which could partly be related to non-comprehensive screening approaches and lack of sustained lead optimization. The origin of these marine fungal metabolites is varied as their habitats have been reported from various sources such as sponge, algae, mangrove derived fungi, and fungi from bottom sediments. The importance of these natural compounds is based on their cytotoxicity and related activities that emanate from the diversity in their chemical structures and functional groups present on them. This review covers the majority of anticancer compounds isolated from marine fungi during 2012-2016 against specific cancer cell lines.
由于具有作为治疗剂的潜力，海洋真菌的代谢产物在药物发现领域备受关注。已从各种来源发现了许多与海洋真菌相关的代谢产物，这些来源已知具有一系列作为抗菌、抗病毒和抗癌剂的活性。尽管已经报道了一千多种基于海洋真菌的代谢产物，但它们都尚未进入市场，这可能部分与非全面的筛选方法以及缺乏持续的先导化合物优化有关。这些海洋真菌代谢产物的来源各不相同，因为它们的栖息地已从各种来源报道，如海绵、藻类、红树林衍生真菌和来自底部沉积物的真菌。这些天然化合物的重要性基于它们的细胞毒性以及因其化学结构和存在的官能团的多样性而产生的相关活性。本综述涵盖了2012年至2016年期间从海洋真菌中分离出的针对特定癌细胞系的大多数抗癌化合物。
