Prajapati Jignesh, Goswami Dweipayan, Rawal Rakesh M
Department of Biochemistry & Forensic Science, University School of Sciences, Gujarat University, Ahmedabad, 380009, Gujarat, India.
Department of Microbiology & Biotechnology, University School of Sciences, Gujarat University, Ahmedabad, 380009, Gujarat, India.
Curr Res Pharmacol Drug Discov. 2021 Sep 1;2:100050. doi: 10.1016/j.crphar.2021.100050. eCollection 2021.
Cancer is a multifactorial disease with a convoluted genesis and progression. The emergence of multidrug resistance to presently be offered drug and relapse is by far, the most critical concern to tackle this deteriorating disease. Henceforth, there is undeniably an inflated necessity for safe, promising, and less harmful new anticancer drugs. Natural compounds from various sources like plants, animals, and microorganisms have occupied a center stage in drug discovery due to their tremendous chemical diversity and potential as therapeutic agents. Endophytic microbes are symbiotically associated with plants and have been proven to produce novel or analogues of host bioactive metabolites exhibiting a variety of biological activities including anticancer activity. This review emphasizes on structurally diverse unprecedented anticancer natural compounds that have been reported exclusively from endophytic fungi from 2016 to 2020. It covers chemical nature of metabolites, its fungal source associated with terrestrial, as well as marine plants and anticancer activity based on their cytotoxicity profile against various cancer cell lines. Many of these fungal metabolites with promising anticancer activity can be used as lead molecules for experiments and deserve special attention from scientists for further and clinical research.
癌症是一种具有复杂起源和进展的多因素疾病。目前对现有药物产生多药耐药性以及癌症复发的问题，是攻克这种日益恶化疾病最关键的关注点。因此，毫无疑问，对于安全、有前景且危害较小的新型抗癌药物的需求大幅增加。来自植物、动物和微生物等各种来源的天然化合物，因其巨大的化学多样性和作为治疗剂的潜力，在药物发现中占据了核心地位。内生微生物与植物共生，并且已被证明能产生宿主生物活性代谢物的新化合物或类似物，表现出包括抗癌活性在内的多种生物活性。本综述着重介绍了2016年至2020年间仅从内生真菌中报道的结构多样的前所未有的抗癌天然化合物。它涵盖了代谢物的化学性质、与陆地以及海洋植物相关的真菌来源，以及基于其对各种癌细胞系的细胞毒性概况的抗癌活性。许多这些具有前景的抗癌活性的真菌代谢物可作为实验的先导分子，值得科学家们给予特别关注以进行进一步研究和临床研究。
