锂与肾脏
Lithium and the kidney.
作者信息
MacDonald K J, Little P J, Bailey R R
出版信息
N Z Med J. 1979 Oct 24;90(646):323-5.
PMID:293541
Abstract
Three middle-aged women treated with lithium carbonate for a manic-depressive illness have had complicating nephrogenic diabetes insipidus, renal tubular acidosis, acute reversible renal functional impairment in association with hypercalcaemia, or irreversible chronic renal damage. Renal toxicity developed in the presence of normal levels of lithium in the serum. The possibility of permanent renal damage as a result of long-term lithium therapy is of major concern.
摘要
三名患有躁郁症并接受碳酸锂治疗的中年女性出现了并发症，包括肾性尿崩症、肾小管酸中毒、与高钙血症相关的急性可逆性肾功能损害或不可逆的慢性肾损伤。在血清锂水平正常的情况下发生了肾毒性。长期锂治疗导致永久性肾损伤的可能性是主要关注点。
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