长期服用锂剂后出现持续性肾性尿崩症、肾小管性蛋白尿、氨基酸尿和甲状旁腺激素抵抗。
Persistent nephrogenic diabetes insipidus, tubular proteinuria, aminoaciduria, and parathyroid hormone resistance following longterm lithium administration.
作者信息
Neithercut W D, Spooner R J, Hendry A, Dagg J H
机构信息
Department of Pathological Biochemistry, Western Infirmary, Glasgow, UK.
出版信息
Postgrad Med J. 1990 Jun;66(776):479-82. doi: 10.1136/pgmj.66.776.479.
We report a patient who developed persistent nephrogenic diabetes insipidus associated with renal tubular acidosis, renal resistance to parathyroid hormone, aminoaciduria and proximal tubule pattern proteinuria in the presence of a reduced glomerular filtration rate (19-24 ml/min). A review of the previous reports of persistent nephrogenic diabetes insipidus revealed that in all patients the glomerular filtration rate had been less than 60 ml/min at presentation. Chronic renal failure may therefore predispose to the development of persistent nephrogenic diabetes insipidus in patients receiving lithium.
我们报告了一名患者，该患者在肾小球滤过率降低（19 - 24 ml/分钟）的情况下，出现了与肾小管酸中毒、肾对甲状旁腺激素抵抗、氨基酸尿和近端肾小管型蛋白尿相关的持续性肾性尿崩症。对既往持续性肾性尿崩症报告的回顾显示，所有患者在就诊时肾小球滤过率均低于60 ml/分钟。因此，慢性肾衰竭可能使接受锂治疗的患者易患持续性肾性尿崩症。
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