Rodgers V D, Fassett R, Kagnoff M F
Gastroenterology. 1986 Mar;90(3):552-8. doi: 10.1016/0016-5085(86)91108-x.
Enteric infections are common in homosexual men. We have characterized the phenotypic distribution of small intestinal mononuclear cells among healthy homosexual men, homosexual men with lymphadenopathy syndrome, homosexual men with acquired immunodeficiency syndrome (AIDS), and a group of healthy heterosexual men. Total numbers of T lymphocytes in the small intestinal mucosa were significantly decreased in homosexual men with lymphadenopathy syndrome and AIDS. This decrease was most striking among the Leu-3a T-cell subset usually associated with helper/inducer function. The proportion of mucosal T cells reacting with Leu-2a (cytotoxic/suppressor phenotype) and lymphoid cells having the T305 antigen was significantly increased only in AIDS subjects. Both lymphadenopathy syndrome and AIDS subjects had a significant reversal of the normal mucosal helper/suppressor T-cell ratio. Mucosal helper/suppressor T-cell ratios and the distribution of mucosal mononuclear cells were normal in healthy homosexual men, although the same individuals had reversed helper/suppressor ratios among circulating T cells. Enteric infections in healthy homosexual men likely reflect sexual practices, and not a primary abnormality in intestinal mucosal immunity. In contrast, specific abnormalities in intestinal mucosal immunity may contribute to the persistent and opportunistic enteric infections that occur in AIDS.
肠道感染在男同性恋者中很常见。我们已对健康男同性恋者、患有淋巴结病综合征的男同性恋者、患有获得性免疫缺陷综合征（艾滋病）的男同性恋者以及一组健康异性恋男性的小肠单核细胞表型分布进行了特征描述。患有淋巴结病综合征和艾滋病的男同性恋者小肠黏膜中的T淋巴细胞总数显著减少。这种减少在通常与辅助/诱导功能相关的Leu - 3a T细胞亚群中最为明显。仅在艾滋病患者中，与Leu - 2a反应的黏膜T细胞比例（细胞毒性/抑制表型）和具有T305抗原的淋巴细胞比例显著增加。淋巴结病综合征患者和艾滋病患者的正常黏膜辅助/抑制性T细胞比例均出现显著逆转。健康男同性恋者的黏膜辅助/抑制性T细胞比例以及黏膜单核细胞的分布是正常的，尽管同一人群的循环T细胞中辅助/抑制比例出现了逆转。健康男同性恋者的肠道感染可能反映了性行为，而非肠道黏膜免疫的原发性异常。相比之下，肠道黏膜免疫的特定异常可能导致艾滋病患者发生持续性和机会性肠道感染。
