Ammann A J, Abrams D, Conant M, Chudwin D, Cowan M, Volberding P, Lewis B, Casavant C
Clin Immunol Immunopathol. 1983 Jun;27(3):315-25. doi: 10.1016/0090-1229(83)90084-3.
Homosexual men with Kaposi sarcoma, lymphadenopathy syndrome, opportunistic infection, and nonhomosexual traditional Kaposi sarcoma were evaluated for B cell, T cell, and complement immunity and compared to normal controls and homosexual controls. No significant immunologic abnormalities were found in the traditional Kaposi group. All homosexual groups, including the homosexual controls, had a significant decrease in the helper/suppressor cell ratio. Functional abnormalities of T-cell immunity were observed in the homosexual Kaposi sarcoma, lymphadenopathy syndrome, and opportunistic infection groups. Significant elevations of IgG, IgM, IgA, and IgE were found in the lymphadenopathy group, while only IgG and IgA were elevated in the Kaposi sarcoma group. C3, C4, and immune complexes were normal, while total hemolytic complement activity was increased in the Kaposi sarcoma and lymphadenopathy syndrome groups.
对患有卡波西肉瘤、淋巴结病综合征、机会性感染的同性恋男性以及非同性恋的传统卡波西肉瘤患者进行了B细胞、T细胞和补体免疫评估，并与正常对照和同性恋对照进行比较。在传统卡波西肉瘤组中未发现明显的免疫异常。所有同性恋组，包括同性恋对照组，辅助/抑制细胞比值均显著降低。在同性恋卡波西肉瘤、淋巴结病综合征和机会性感染组中观察到T细胞免疫功能异常。淋巴结病组中IgG、IgM、IgA和IgE显著升高，而卡波西肉瘤组仅IgG和IgA升高。C3、C4和免疫复合物正常，而卡波西肉瘤和淋巴结病综合征组的总溶血补体活性增加。
