Alshaikh Belal, Salman Omar, Soliman Nancy, Ells Anna, Yusuf Kamran
Department of Pediatrics, University of Calgary Cumming School of Medicine, Calgary, Canada.
University of Toronto at Scarborough, Toronto, Canada.
BMJ Open Ophthalmol. 2017 Jun 19;1(1):e000049. doi: 10.1136/bmjophth-2016-000049. eCollection 2017.
To evaluate the relationship between pre-eclampsia and development of retinopathy of prematurity (ROP) in infants with birth weight of <1500 g and/or gestation <31 weeks.
A retrospective cohort study comprising infants born to mothers with pre-eclampsia between January 2007 and June 2010 at a single tertiary care centre. Their ROP outcome was compared with infants born to the next two normotensive mothers with a ±1 week gestational age difference. Pearson χ test was used for categorical variables and Mann-Whitney U test was used for continuous variables. Multivariable regression was used to estimate the OR of ROP with prenatal pre-eclampsia exposure and adjust for confounders.
Of the 97 infants in the pre-eclampsia group, 27 (27%) developed ROP and of the 185 infants in the normotensive group, 50 (27%) developed ROP. On multivariable regression modelling, pre-eclampsia was not a risk factor for the development of ROP (OR 1.4, 95% CI 0.46 to 4.1). Gestational age, intrauterine growth restriction and blood transfusion were significant risk factors for the development of ROP.
In our cohort, pre-eclampsia was not a significant risk factor for the development of ROP. Intrauterine growth restricted infants of pre-eclamptic and normotensive mothers were at higher risk of ROP.
评估子痫前期与出生体重<1500 g和/或孕周<31周的婴儿发生早产儿视网膜病变（ROP）之间的关系。
一项回顾性队列研究，纳入2007年1月至2010年6月在一家三级医疗中心出生的母亲患有子痫前期的婴儿。将他们的ROP结局与接下来的两名血压正常且孕周相差±1周的母亲所生婴儿进行比较。分类变量采用Pearson χ检验，连续变量采用Mann-Whitney U检验。多变量回归用于估计产前暴露于子痫前期发生ROP的比值比（OR）并对混杂因素进行校正。
子痫前期组的97名婴儿中，27名（27%）发生ROP；血压正常组的185名婴儿中，50名（27%）发生ROP。在多变量回归模型中，子痫前期不是发生ROP的危险因素（OR 1.4，95%CI 0.46至4.1）。孕周、宫内生长受限和输血是发生ROP的显著危险因素。
在我们的队列中，子痫前期不是发生ROP的显著危险因素。子痫前期和血压正常母亲的宫内生长受限婴儿发生ROP的风险更高。
