Deol Rupinder, Lee Kathryn A, Kandula Namratha R, Kanaya Alka M
Department of Family Health Care Nursing, University of California, San Francisco, San Francisco, CA 94143.
Division of General Internal Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.
Obes Med. 2018 Mar;9:1-6. doi: 10.1016/j.obmed.2017.11.001. Epub 2017 Dec 1.
To examine the association between glycaemia status and the risk for obstructive sleep apnoea (OSA) in a cohort of South Asians living in the United States.
A secondary analysis of a community based cohort of 899 participants from the Mediators of Atherosclerosis in South Asians Living in America (MASALA) study. The Berlin Questionnaire was used to screen for OSA.
Almost one in four (24%) South Asians was at high risk for OSA. Compared to the normal glucose tolerance group (18%), high risk of OSA was significantly more likely in the prediabetes (24%) and diabetes (32%) groups ( = .007). More men (28%) than women (18%) were at high risk of OSA. Risk for OSA was also associated with higher haemoglobin A1c values, hypertension, large waist circumference, and BMI > 27.5 kg/m. In a multivariate regression analysis, sleep disordered breathing (SDB) remained significantly associated with higher haemoglobin A1c values, even after controlling for waist circumference and other demographic and clinical factors.
The risk for SDB and OSA was high among South Asian men and women. Given the association between dysglycaemia and risk for OSA, these health issues require simultaneous clinical assessment. Future studies using objective sleep measures such as polysomnography are warranted in the diagnosis and treatment of OSA in the South Asian adult population already at high risk for dysglycaemia.
在一群生活在美国的南亚人群体中，研究血糖状态与阻塞性睡眠呼吸暂停（OSA）风险之间的关联。
对来自“生活在美国的南亚人动脉粥样硬化的介导因素（MASALA）研究”的899名参与者的社区队列进行二次分析。使用柏林问卷筛查OSA。
近四分之一（24%）的南亚人有患OSA的高风险。与正常糖耐量组（18%）相比，糖尿病前期（24%）和糖尿病组（32%）患OSA的高风险显著更高（P = 0.007）。有OSA高风险的男性（28%）多于女性（18%）。OSA风险还与较高的糖化血红蛋白值、高血压、大腰围以及BMI>27.5kg/m²相关。在多变量回归分析中，即使在控制了腰围以及其他人口统计学和临床因素之后，睡眠呼吸紊乱（SDB）仍与较高的糖化血红蛋白值显著相关。
南亚男性和女性中SDB和OSA的风险较高。鉴于血糖异常与OSA风险之间的关联，这些健康问题需要同时进行临床评估。对于已经有高血糖风险的南亚成年人群体，未来有必要使用多导睡眠图等客观睡眠测量方法来研究OSA的诊断和治疗。
