动脉粥样硬化及相关心脑血管疾病中循环炎症生物标志物的当前进展
Current advances in circulating inflammatory biomarkers in atherosclerosis and related cardio-cerebrovascular diseases.
作者信息
Lv Jun-Xuan, Kong Qi, Ma Xin
机构信息
Department of Neurology, Xuanwu Hospital of Capital Medical University, National Clinical Research Center for Geriatric Disorders, Clinical Center for Cardio-cerebrovascular Disease Capital Medical University, Beijing 100053, China.
出版信息
Chronic Dis Transl Med. 2017 Nov 26;3(4):207-212. doi: 10.1016/j.cdtm.2017.09.002. eCollection 2017 Dec.
Abstract
Atherosclerosis (AS) is a systemic chronic disease affecting both the coronary and cerebral arteries. Inflammation plays a key role in the initiation and progression of AS, and numerous inflammatory factors have been proposed as potential biomarkers. This article reviews recent research in studies on major circulating inflammatory biomarkers to identify surrogates that may reflect processes associated with AS development and the risk of AS-related vascular events, such as Von Willebrand factor, lectin-like oxidized low-density-lipoprotein receptor-1, soluble urokinase plasminogen activator receptor, regulated upon activation, normal T-cell expressed and secreted, and microparticles, which may provide new perspectives for clinical AS evaluation and risk stratification.
摘要
动脉粥样硬化（AS）是一种影响冠状动脉和脑动脉的全身性慢性疾病。炎症在AS的发生和发展中起关键作用，并且众多炎症因子已被提出作为潜在的生物标志物。本文综述了近期关于主要循环炎症生物标志物的研究，以确定可能反映与AS发展及AS相关血管事件风险相关过程的替代指标，如血管性血友病因子、凝集素样氧化低密度脂蛋白受体-1、可溶性尿激酶型纤溶酶原激活物受体、活化后正常T细胞表达和分泌的因子以及微粒，这可能为临床AS评估和风险分层提供新的视角。
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