Institute for Atherosclerosis Research, Skolkovo Innovative Center, 121609 Moscow, Russia.
AP Avtsyn Research Institute of Human Morphology, 3 Tsyurupa Street, 117418 Moscow, Russia.
Int J Mol Sci. 2022 Feb 24;23(5):2504. doi: 10.3390/ijms23052504.
For the past several decades, humanity has been dealing with HIV. This disease is one of the biggest global health problems. Fortunately, modern antiretroviral therapy allows patients to manage the disease, improving their quality of life and their life expectancy. In addition, the use of these drugs makes it possible to reduce the risk of transmission of the virus to almost zero. Atherosclerosis is another serious pathology that leads to severe health problems, including disability and, often, the death of the patient. An effective treatment for atherosclerosis has not yet been developed. Both types of immune response, innate and adaptive, are important components of the pathogenesis of this disease. In this regard, the peculiarities of the development of atherosclerosis in HIV carriers are of particular scientific interest. In this review, we have tried to summarize the data on atherosclerosis and its development in HIV carriers. We also looked at the classic therapeutic methods and their features concerning the concomitant diagnosis.
在过去的几十年中，人类一直在与 HIV 作斗争。这种疾病是全球最大的健康问题之一。幸运的是，现代抗逆转录病毒疗法使患者能够控制这种疾病，提高他们的生活质量和预期寿命。此外，这些药物的使用使得将病毒传播的风险降低到几乎为零成为可能。动脉粥样硬化是另一种导致严重健康问题的严重病理学，包括残疾，而且通常还会导致患者死亡。目前还没有开发出有效的动脉粥样硬化治疗方法。先天和适应性两种免疫反应都是这种疾病发病机制的重要组成部分。在这方面，HIV 携带者中动脉粥样硬化发展的特点具有特别重要的科学意义。在这篇综述中，我们试图总结关于 HIV 携带者中动脉粥样硬化及其发展的数据。我们还研究了经典的治疗方法及其在合并诊断中的特点。
