Oakley C R, Gollnick P D
Histochemistry. 1985;83(6):555-60. doi: 10.1007/BF00492460.
Rats were used in this study to determine the time course of conversion of muscle fiber types. The right or left gastrocnemius muscle was removed thereby causing an overload on the ipsilateral soleus and plantaris muscles. The contralateral limb served as a control. The type II to type I fiber conversion was followed histochemically in the soleus and plantaris muscles for one to six weeks following surgery. Muscle sections were stained for myofibrillar actomyosin ATPase and NADH tetrazolium reductase. The type I population in the soleus muscle was 99.3% six weeks after synergist removal. The plantaris muscle underwent a two fold increase in the percentage of type I fibers after six weeks. Transitional fibers were prominent in the plantaris muscle and reached their peak at 4% (P less than 0.05) of the total population, four weeks after surgery.
本研究使用大鼠来确定肌纤维类型转换的时间进程。切除右侧或左侧腓肠肌，从而使同侧比目鱼肌和跖肌负荷过载。对侧肢体作为对照。术后1至6周，通过组织化学方法追踪比目鱼肌和跖肌中II型向I型纤维的转换。肌肉切片用肌原纤维肌动球蛋白ATP酶和NADH四氮唑还原酶染色。协同肌切除六周后，比目鱼肌中I型纤维比例为99.3%。六周后，跖肌中I型纤维百分比增加了两倍。术后四周，过渡性纤维在跖肌中很突出，占总数的4%（P小于0.05），达到峰值。
