Acuff Samuel F, Luciano Matthew T, Soltis Kathryn E, Joyner Keanan J, McDevitt-Murphy Meghan, Murphy James G
Department of Psychology.
Department of Psychology, Florida State University.
Exp Clin Psychopharmacol. 2018 Apr;26(2):177-185. doi: 10.1037/pha0000181. Epub 2018 Jan 22.
Symptoms of posttraumatic stress (PTS) show significant comorbidity with alcohol use, but little is known about the mechanisms that might account for this comorbidity. Deficits in reward functioning have long been implicated in alcohol misuse and more recently in PTS reactions, but no study has examined whether reward deprivation may serve as a transdiagnostic risk factor for comorbid PTS-alcohol misuse. The current cross-sectional study sought to test the behavioral economic hypothesis that reward deprivation would be related to both PTS symptoms and alcohol problems, and would mediate the relation between PTS symptoms and alcohol problems in college students. We recruited a diverse sample of urban college students (N = 203, M = 21.5 years, SD = 5.5; 79.5% female; 56.8% White, 28.1% Black, .9% Asian, 9.8% Multiracial) who endorsed both alcohol use and PTS symptoms. Reward deprivation (lack of access to, and ability to, experience reward) was related to alcohol problems, and a lack of access to reward was related to PTS symptoms. Furthermore, reward access mediated the relation between PTS symptoms and alcohol problems and craving, after controlling for alcohol use, age, gender, and race. These data provide preliminary support for behavioral economic models of alcohol comorbidity and suggest that treatments for combined PTS and alcohol misuse should attempt to reduce barriers to accessing natural rewards. (PsycINFO Database Record
创伤后应激障碍(PTS)的症状与酒精使用存在显著的共病现象,但对于可能导致这种共病的机制却知之甚少。奖赏功能缺陷长期以来一直被认为与酒精滥用有关,最近也被认为与PTS反应有关,但尚无研究探讨奖赏剥夺是否可能作为PTS与酒精滥用共病的跨诊断风险因素。当前的横断面研究旨在检验行为经济学假设,即奖赏剥夺与PTS症状和酒精问题均相关,并将介导大学生中PTS症状与酒精问题之间的关系。我们招募了一个多样化的城市大学生样本(N = 203,M = 21.5岁,SD = 5.5;79.5%为女性;56.8%为白人,28.1%为黑人,0.9%为亚洲人,9.8%为多种族),这些学生既认可酒精使用又认可PTS症状。奖赏剥夺(无法获得和体验奖赏)与酒精问题相关,而无法获得奖赏与PTS症状相关。此外,在控制了酒精使用、年龄、性别和种族后,获得奖赏介导了PTS症状与酒精问题及渴望之间的关系。这些数据为酒精共病的行为经济学模型提供了初步支持,并表明针对PTS与酒精滥用合并症的治疗应尝试减少获得自然奖赏的障碍。(PsycINFO数据库记录