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现代衰老研究简史。

A brief history of modern aging research.

机构信息

Glenn Center for the Science of Aging, Department of Biology, Koch Institute, MIT, Cambridge, MA 02139, USA.

出版信息

Exp Gerontol. 2018 Apr;104:35-42. doi: 10.1016/j.exger.2018.01.018. Epub 2018 Jan 31.

Abstract

Over the last few decades, aging research has emerged as a vibrant area of rigorous scientific study. With its humble beginnings in yeast and worms, the field has progressed so dramatically that scientists are now able to extend the lifespan of mice with the use of small molecule drugs. However, it was not too long ago that answering the more basic question, whether aging was amenable to scientific study, was itself a topic of contentious debate. To begin to understand how a field that was initially thought of as pseudoscience has come so far, it is instructive to understand its roots in both theory and practice.

摘要

在过去的几十年中,衰老研究已经成为一个充满活力的严谨科学研究领域。该领域从酵母和蠕虫开始,发展如此迅速,以至于科学家现在能够使用小分子药物来延长老鼠的寿命。然而,就在不久前,回答更基本的问题,即衰老是否可以进行科学研究,本身就是一个有争议的话题。为了开始理解一个最初被认为是伪科学的领域是如何走得这么远的,了解其在理论和实践中的根源是很有启发性的。

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