Neurocomputation Neuroimaging Unit, Department of Education and Psychology, and Center for Cognitive Neuroscience Berlin, Freie Universität Berlin, Berlin, Germany.
Wellcome Centre for Human Neuroimaging, Institute of Neurology, University College London, London, UK.
Eur J Neurosci. 2018 Feb;47(4):314-320. doi: 10.1111/ejn.13824. Epub 2018 Feb 5.
An important implication of several recent accounts of motor control is that sensory feedback from self-generated movements is relatively attenuated based on predictions issued by the agent's motor system. Such a relative attenuation of sensory information during actions has already been demonstrated in the somatosensory domain. Here, we used functional magnetic resonance imaging (fMRI) and a virtual reality-based setup to investigate a potential attenuation of brain responses to realistic visual movement feedback during active vs. passive right-hand movements. The participants' right unseen hand was rotated either by the participants themselves or by the experimenter, while the participants received visual movement feedback via a photorealistic virtual 3D hand driven by their real hand movements, or received no visual feedback. We observed a significant interaction between movement type (active vs. passive) and movement feedback (vision vs. no vision) in the right superior temporal sulcus (STS), which showed relatively attenuated blood-oxygen-level-dependent (BOLD) signal differences in movements with vs. without visual feedback when those movements were actively vs. passively executed. This finding suggests that STS activity caused by visual feedback from the moving body may be attenuated based on the agent's motor predictions.
最近有几项关于运动控制的研究表明，基于主体运动系统发出的预测，来自自身运动的感觉反馈会被相对抑制。在体感领域已经证明了这种在动作过程中对感觉信息的相对抑制。在这里，我们使用功能磁共振成像（fMRI）和基于虚拟现实的设置来研究在主动和被动右手运动期间，对现实视觉运动反馈的大脑反应是否存在潜在的抑制。参与者的右手在看不见的情况下要么由参与者自己旋转，要么由实验者旋转，同时参与者通过由真实手部运动驱动的逼真的虚拟 3D 手接收视觉运动反馈，或者不接收视觉反馈。我们在右侧颞上沟（STS）中观察到运动类型（主动与被动）和运动反馈（视觉与无视觉）之间的显著交互作用，当运动是主动进行时，STS 中的血氧水平依赖（BOLD）信号差异相对抑制，而当运动是被动进行时，无论是否有视觉反馈。这一发现表明，来自运动身体的视觉反馈引起的 STS 活动可能会根据主体的运动预测而被抑制。
