Christensen Mark Schram, Lundbye-Jensen Jesper, Petersen Nicolas, Geertsen Svend Sparre, Paulson Olaf B, Nielsen Jens Bo
Institute of Exercise and Sport Sciences, University of Copenhagen, Nørre Allé 51, DK-2200 København N, Denmark.
Cereb Cortex. 2007 Aug;17(8):1906-17. doi: 10.1093/cercor/bhl101. Epub 2006 Oct 23.
The objective of this study was to investigate brain areas involved in distinguishing sensory events caused by self-generated movements from similar sensory events caused by externally generated movements using functional magnetic resonance imaging. Subjects performed 4 types of movements: 1) self-generated voluntary movement with visual feedback, 2) externally generated movement with visual feedback, 3) self-generated voluntary movement without visual feedback, and 4) externally generated movement without visual feedback, this design. This factorial design makes it possible to study which brain areas are activated during self-generated ankle movements guided by visual feedback as compared with externally generated movements under similar visual and proprioceptive conditions. We found a distinct network, comprising the posterior parietal cortex and lateral cerebellar hemispheres, which showed increased activation during visually guided self-generated ankle movements. Furthermore, we found differential activation in the cerebellum depending on the different main effects, that is, whether movements were self- or externally generated regardless of visual feedback, presence or absence of visual feedback, and activation related to proprioceptive input.
本研究的目的是利用功能磁共振成像技术，调查大脑中参与区分由自身产生的运动所引起的感觉事件与由外部产生的运动所引起的类似感觉事件的区域。受试者进行了4种类型的运动：1）有视觉反馈的自身产生的自主运动；2）有视觉反馈的外部产生的运动；3）无视觉反馈的自身产生的自主运动；4）无视觉反馈的外部产生的运动，采用这种设计。这种析因设计使得我们能够研究在视觉反馈引导下的自身产生的踝关节运动过程中，与在相似视觉和本体感觉条件下的外部产生的运动相比，哪些脑区会被激活。我们发现了一个独特的网络，包括后顶叶皮层和小脑外侧半球，在视觉引导的自身产生的踝关节运动过程中，该网络显示出激活增加。此外，我们发现小脑的激活存在差异，这取决于不同的主要效应，即无论有无视觉反馈，运动是由自身还是外部产生，以及与本体感觉输入相关的激活情况。
