Son Hee-Kyoung, Shin Hye-Won, Jang Eun-Seok, Moon Byoung-Seok, Lee Choong-Hwan, Lee Jae-Joon
1 Department of Food and Nutrition, Chosun University , Gwangju, Korea.
2 Foods Research Institute , CJ CheilJedang Corp., Suwon, Korea.
J Med Food. 2018 Mar;21(3):233-243. doi: 10.1089/jmf.2017.4007. Epub 2018 Jan 22.
In this study, we compared the antiobesity effects between gochujangs prepared using different koji products and Tabasco hot sauce in rats fed a high-fat diet (HFD). Male Sprague-Dawley rats were fed HFD containing four different types of 10% gochujang powder or 0.25% commercial Tabasco sauce powder for 8 weeks. The body weight gain, liver and epididymal and mesenteric fat pad weights, serum leptin levels, and lipogenesis-related mRNA levels of HFD-gochujang supplementation groups were significantly decreased compared with those of the HFD group. In addition, gochujang supplement significantly reduced adipocyte size; hepatic triglyceride and total cholesterol levels; the occurrence of fatty liver deposits and steatosis by inhibiting lipogenesis through downregulation of fatty acid synthase, acetly-CoA carboxylase, and glucose-6-phosphate-dehydrogenase. These effects were greater in the gochujang-supplemented groups than the Tabasco hot sauce-supplemented group. The gochujang prepared by nutritious giant embryo rice koji and soybean koji was most effective in terms of antiobesity effects, compared with the other tested gochujangs. In gochujangs, the antiobesity effects are mediated by high levels of secondary metabolites such as isoflavone, soyasaponin, capsaicin, and lysophosphatidylcholine. The current results indicated that the gochujang products have the potential to reduce fat accumulation and obesity.
在本研究中，我们比较了用不同酒曲产品制备的辣椒酱与塔巴斯科辣酱对高脂饮食（HFD）喂养大鼠的抗肥胖作用。雄性Sprague-Dawley大鼠喂食含有四种不同类型10%辣椒酱粉末或0.25%市售塔巴斯科辣酱油粉末的高脂饮食，持续8周。与高脂饮食组相比，高脂饮食-辣椒酱补充组的体重增加、肝脏、附睾和肠系膜脂肪垫重量、血清瘦素水平以及脂肪生成相关mRNA水平均显著降低。此外，辣椒酱补充剂显著减小了脂肪细胞大小；降低了肝脏甘油三酯和总胆固醇水平；通过下调脂肪酸合酶、乙酰辅酶A羧化酶和葡萄糖-6-磷酸脱氢酶抑制脂肪生成，减少了脂肪肝沉积物和脂肪变性的发生。这些作用在辣椒酱补充组中比塔巴斯科辣酱补充组更大。与其他测试的辣椒酱相比，由营养巨胚米曲和大豆曲制备的辣椒酱在抗肥胖作用方面最有效。在辣椒酱中，抗肥胖作用是由高水平的次生代谢产物如异黄酮、大豆皂苷、辣椒素和溶血磷脂酰胆碱介导的。目前的结果表明，辣椒酱产品具有减少脂肪堆积和肥胖的潜力。
