Tange Yoshihiro, Yoshitake Shigenori, Takesawa Shingo
Department of Medical Engineering, Kyushu University of Health and Welfare, 1714-1 Yoshinomachi, Nobeoka, Miyazaki, Japan.
J Artif Organs. 2018 Sep;21(3):392-395. doi: 10.1007/s10047-018-1022-9. Epub 2018 Jan 22.
Intravenous oxygenation has demonstrated significant increase in partial pressure of oxygen (PO) in animal models. A highly dissolved oxygen solution might be able to provide a sufficient level of oxygen delivery to the tissues and organs in patients with hypoxia. However, conventional fluid oxygenation methods have required the use of original devices. If simpler oxygenation of a solution is possible, it will be a useful strategy for application in clinical practice. We simply developed its administration by injection of either air or oxygen gas into conventional saline. We determined the PO values in the solutions in comparison with conventional saline in vitro. To examine the effects of the administration of the new solutions on the blood gas profile, we diluted bovine blood with either conventional or the new solutions and analyzed PO, oxygen saturation (SO) and total oxygen content. PO levels in the blood and new solution mixture significantly increased with each additional injected gas volume. Significant increases in the PO and SO of the bovine blood were found in those blood samples with the new solution, as compared with those with the control solution. These results suggest that this solution promotes oxygen delivery to the hypoxic tissue and recovery from hypoxia. This method is simpler and easier than previous methods.
静脉氧合已在动物模型中证明可显著提高氧分压（PO）。一种高度溶解的氧溶液或许能够为缺氧患者的组织和器官提供足够水平的氧输送。然而，传统的液体氧合方法需要使用原始设备。如果能够实现溶液更简单的氧合，那将是一种可应用于临床实践的有用策略。我们只是通过向传统盐水中注入空气或氧气来开发其给药方式。我们在体外将溶液中的PO值与传统盐水进行了比较。为了研究新溶液给药对血气指标的影响，我们用传统溶液或新溶液稀释牛血，并分析PO、氧饱和度（SO）和总氧含量。随着每次额外注入气体量的增加，血液与新溶液混合物中的PO水平显著升高。与对照溶液相比，在使用新溶液的牛血样本中发现PO和SO显著增加。这些结果表明，这种溶液促进了向缺氧组织的氧输送以及从缺氧状态的恢复。这种方法比以前的方法更简单、更容易。
