Ram Maya, Hiersch Liran, Ashwal Eran, Nassie Daniel, Lavie Anat, Yogev Yariv, Aviram Amir
Departments of Obstetrics and Gynecology, Lis Maternity and Women's Hospital, Tel Aviv Sourasky Medical Center (affiliated with the Sackler Faculty of Medicine, Tel Aviv University), Tel Aviv, Israel.
The Helen Schneider Hospital for Women, Rabin Medical Center (affiliated with the Sackler Faculty of Medicine, Tel Aviv University), Petah Tikva, Israel.
Arch Gynecol Obstet. 2018 Apr;297(4):907-913. doi: 10.1007/s00404-018-4677-9. Epub 2018 Jan 22.
To stratify maternal and neonatal outcomes of trials of labor after previous cesarean delivery (TOLAC) by gestational age.
Retrospective cohort study of all singleton pregnancies with one previous cesarean delivery in TOLAC at term between 2007 and 2014. We compared outcomes of delivery at an index gestational week, with outcomes of women who remained undelivered at this index gestational week (ongoing pregnancy). Odds ratios and 95% confidence intervals were adjusted for maternal age, previous vaginal delivery, induction of labor, epidural use, presence of meconium, and birth weight > 4000 g.
Overall, 2849 women were eligible for analysis. Of those, 2584 (90.7%) had a successful TOLAC and 16 women (0.56%) had uterine rupture. Those rates did not differ significantly for any gestational age (GA) group. Following adjustment for possible confounders, GA was not found to be independently associated with adverse maternal or neonatal outcomes.
Among women at term with a single previous cesarean delivery, GA at delivery was not found to be an independent risk factor for TOLAC success or uterine rupture. We suggest that GA by itself will not serve as an argument for or against TOLAC.
按孕周对既往剖宫产术后试产(TOLAC)的母婴结局进行分层。
对2007年至2014年期间足月行TOLAC且既往有一次剖宫产史的所有单胎妊娠进行回顾性队列研究。我们比较了在某个索引孕周时的分娩结局与在该索引孕周时仍未分娩(继续妊娠)的女性的结局。对产妇年龄、既往阴道分娩史、引产、硬膜外使用、胎粪情况以及出生体重>4000g进行了比值比和95%置信区间的校正。
总体而言,2849名女性符合分析条件。其中,2584名(90.7%)TOLAC成功,16名女性(0.56%)发生子宫破裂。在任何孕周(GA)组中,这些发生率均无显著差异。在对可能的混杂因素进行校正后,未发现GA与不良母婴结局独立相关。
在既往有一次剖宫产史的足月女性中,分娩时的GA并非TOLAC成功或子宫破裂的独立危险因素。我们建议,GA本身不能作为支持或反对TOLAC的依据。