Department of Molecular and Cellular Biochemistry, Department of Biology, Indiana University, Bloomington, IN, USA.
Adv Exp Med Biol. 2017;1042:99-115. doi: 10.1007/978-981-10-6955-0_5.
Organisms within the archaeal domain of life possess a simplified version of the eukaryotic DNA replication machinery. While some archaea possess a bacterial-like mode of DNA replication with single origins of replication per chromosome, the majority of species characterized to date possess chromosomes with multiple replication origins. Genetic, structural, and biochemical studies have revealed the nature of archaeal origin specification. Recent work has begun to shed light on the mechanisms of replication initiation in these organisms.
生命的古菌域中的生物拥有简化的真核生物 DNA 复制机制。虽然一些古菌具有类似细菌的 DNA 复制模式，每个染色体只有一个复制起点，但迄今为止已鉴定的大多数物种的染色体都具有多个复制起点。遗传、结构和生化研究揭示了古菌原点特征的本质。最近的工作开始揭示这些生物中复制起始的机制。
