血浆渗透压和血清钠急性升高对运动时交感神经输出及血压反应的影响。
The influence of acute elevations in plasma osmolality and serum sodium on sympathetic outflow and blood pressure responses to exercise.
作者信息
Brian Michael S, Matthews Evan L, Watso Joseph C, Babcock Matthew C, Wenner Megan M, Rose William C, Stocker Sean D, Farquhar William B
机构信息
Department of Kinesiology and Applied Physiology, University of Delaware , Newark, Delaware.
Department of Health and Human Performance, Plymouth State University , Plymouth, New Hampshire.
出版信息
J Neurophysiol. 2018 Apr 1;119(4):1257-1265. doi: 10.1152/jn.00559.2017. Epub 2017 Dec 13.
Elevated plasma osmolality (pOsm) has been shown to increase resting sympathetic nerve activity in animals and humans. The present study tested the hypothesis that increases in pOsm and serum sodium (sNa) concentration would exaggerate muscle sympathetic nerve activity (MSNA) and blood pressure (BP) responses to handgrip (HG) exercise and postexercise ischemia (PEI). BP and MSNA were measured during HG followed by PEI before and after a 23-min hypertonic saline infusion (HSI-3% NaCl). Eighteen participants (age 23 ± 1 yr; BMI 24 ± 1 kg/m) completed the protocol; pOsm and sNa increased from pre- to post-HSI (285 ± 1 to 291 ± 1 mosmol/kg HO; 138.2 ± 0.3 to 141.3 ± 0.4 mM; P < 0.05 for both). Resting mean BP (90 ± 2 vs. 92 ± 1 mmHg) and MSNA (11 ± 2 vs. 15 ± 2 bursts/min) were increased pre- to post-HSI ( P < 0.05 for both). Mean BP responses to HG (106 ± 2 vs. 111 ± 2 mmHg, P < 0.05) and PEI (102 ± 2 vs. 107 ± 2 mmHg, P < 0.05) were higher post-HSI. Similarly, MSNA during HG (20 ± 2 vs. 29 ± 2 bursts/min, P < 0.05) and PEI (19 ± 2 vs. 24 ± 3 bursts/min, P < 0.05) were greater post-HSI. In addition, the change in MSNA was greater post-HSI during HG (Δ9 ± 2 vs. Δ13 ± 3 bursts/min, P < 0.05). A second set of participants ( n = 13, age 23 ± 1 yr; BMI 24 ± 1 kg/m) completed a time control (TC) protocol consisting of quiet rest instead of an infusion. The TC condition yielded no change in resting sNa, pOsm, mean BP, or MSNA (all P > 0.05); responses to HG and PEI were not different pre- to post-quiet rest ( P > 0.05). In summary, acutely increasing pOsm and sNa exaggerates BP and MSNA responses during HG exercise and PEI. NEW & NOTEWORTHY Elevated plasma osmolality has been shown to increase resting sympathetic activity and blood pressure. This study provides evidence that acute elevations in plasma osmolality and serum sodium exaggerated muscle sympathetic nerve activity and blood pressure responses during exercise pressor reflex activation in healthy young adults.
血浆渗透压（pOsm）升高已被证明会增加动物和人类的静息交感神经活动。本研究检验了以下假设：pOsm和血清钠（sNa）浓度的升高会夸大肌肉交感神经活动（MSNA）以及血压（BP）对手握力（HG）运动和运动后缺血（PEI）的反应。在23分钟的高渗盐水输注（HSI - 3% NaCl）前后，分别在HG后接着PEI的过程中测量BP和MSNA。18名参与者（年龄23±1岁；体重指数24±1 kg/m²）完成了该方案；pOsm和sNa从HSI前到HSI后升高（分别为285±1至291±1 mOsm/kg H₂O；138.2±0.3至141.3±0.4 mM；两者P<0.05）。HSI前后静息平均BP（90±2 vs. 92±1 mmHg）和MSNA（11±2 vs. 15±2次/分钟）升高（两者P<0.05）。HSI后，对HG的平均BP反应（106±2 vs. 111±2 mmHg，P<0.05）和对PEI的平均BP反应（102±2 vs. 107±2 mmHg，P<0.05）更高。同样，HSI后HG期间的MSNA（20±2 vs. 29±2次/分钟，P<0.05）和PEI期间的MSNA（19±2 vs. 24±3次/分钟，P<0.05）更大。此外，HSI后HG期间MSNA的变化更大（Δ9±2 vs. Δ13±3次/分钟，P<0.05）。另一组参与者（n = 13，年龄23±1岁；体重指数24±1 kg/m²）完成了一个时间对照（TC）方案，该方案包括安静休息而非输注。TC条件下，静息sNa、pOsm、平均BP或MSNA均无变化（所有P>0.05）；安静休息前后对HG和PEI的反应无差异（P>0.05）。总之，急性升高pOsm和sNa会夸大HG运动和PEI期间的BP和MSNA反应。新发现与值得注意之处：血浆渗透压升高已被证明会增加静息交感神经活动和血压。本研究提供了证据，表明在健康年轻成年人运动加压反射激活期间，血浆渗透压和血清钠的急性升高会夸大肌肉交感神经活动和血压反应。
Zotero 插件