接受抗逆转录病毒治疗的肥胖和非肥胖成年在押HIV感染者的免疫和病毒学转归
Immunologic and Virologic Outcomes of Obese and Nonobese Incarcerated Adults on Antiretroviral Therapy for HIV Infection.
作者信息
Bunnell Kristen L, Aldossari Arwa, Perkins Connor, Schriever Christopher, Chiampas Thomas D, Young Jeremy D, Patel Mahesh C, Badowski Melissa
机构信息
1 Department of Pharmacy Practice, Section of Infectious Diseases Pharmacotherapy, University of Illinois at Chicago College of Pharmacy, Chicago, IL, USA.
2 Department of Pharmacy Practice, Section of Infectious Diseases Pharmacotherapy, University of Illinois College of Pharmacy, Rockford, IL, USA.
出版信息
J Int Assoc Provid AIDS Care. 2018 Jan-Dec;17:2325957417752261. doi: 10.1177/2325957417752261.
BACKGROUND
Obesity is common among patients with HIV. The objective of this study was to characterize response to antiretroviral therapy (ART) in a cohort of obese incarcerated adults compared to a nonobese cohort.
METHODS
A retrospective matched cohort study was conducted in an HIV telemedicine clinic. Patients with body mass index (BMI) >30 kg/m who received the same ART with >95% adherence for at least 6 months were matched to nonobese patients by age, gender, ART, CD4 count, and viral load at baseline.
RESULTS
Twenty pairs were included, with an average BMI of 24 kg/m in the nonobese cohort and 35 kg/m in the obese cohort. No difference was observed in the proportion of patients who achieved virologic suppression or the change in CD4 count from baseline to 6 to 12 months.
CONCLUSION
This study revealed no differences in immunologic recovery or virologic suppression between obese and nonobese patients in an adult correctional population.
背景
肥胖在艾滋病病毒（HIV）感染者中很常见。本研究的目的是描述一组肥胖的成年在押人员与非肥胖组相比对抗逆转录病毒疗法（ART）的反应。
方法
在一家HIV远程医疗诊所进行了一项回顾性配对队列研究。将体重指数（BMI）>30 kg/m²且接受相同ART治疗、依从性>95%至少6个月的患者，按年龄、性别、ART治疗方案、基线CD4细胞计数和病毒载量与非肥胖患者进行配对。
结果
纳入了20对患者，非肥胖组的平均BMI为24 kg/m²，肥胖组为35 kg/m²。在实现病毒学抑制的患者比例或从基线到6至12个月CD4细胞计数的变化方面，未观察到差异。
结论
本研究表明，在成年惩教人群中，肥胖和非肥胖患者在免疫恢复或病毒学抑制方面没有差异。
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