Arnott S, Chandrasekaran R, Hall I H, Puigjaner L C
Nucleic Acids Res. 1983 Jun 25;11(12):4141-55. doi: 10.1093/nar/11.12.4141.
A fibrous form of poly d(A):poly d(T) has a heteronomous secondary structure which is the first to be confirmed for a polynucleotide duplex: although both chains are 10(1) helices, mutually hydrogen-bonded in the standard (Watson-Crick) fashion, each has a quite different conformation. One chain -- probably poly d(A) -- has C3'-endo-puckered furanose rings characteristic of the A family of polynucleotide secondary structures while the other -- probably poly d(T) -- has the C2'-endo-puckered rings of the B family. Since analogous heteronomous structures could be assumed by DNA-DNA or DNA-RNA duplexes containing more general base sequences the polymorphic range of polynucleotide double-helices may be even greater than we have come to suppose.
聚d(A)：聚d(T)的纤维状形式具有异源二级结构，这是首个被证实的多核苷酸双链体的二级结构：尽管两条链均为10(1)螺旋，以标准（沃森-克里克）方式相互氢键结合，但每条链都有截然不同的构象。一条链——可能是聚d(A)——具有多核苷酸二级结构A家族特有的C3'-内端 puckered呋喃糖环，而另一条链——可能是聚d(T)——具有B家族的C2'-内端 puckered环。由于包含更一般碱基序列的DNA-DNA或DNA-RNA双链体可能呈现类似的异源结构，多核苷酸双螺旋的多态范围可能比我们迄今所认为的更大。
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