State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100050, People's Republic of China.
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100050, People's Republic of China.
Fitoterapia. 2018 Mar;125:147-154. doi: 10.1016/j.fitote.2018.01.005. Epub 2018 Jan 19.
Four new ferulic acid derivatives ligusticumacid A-C (1-3) and ligusticumaldehyde A (4), one new dimer ligusticumacid D (5), and two novel 8-8' lignans ligusticumacid E-F (6-7) were isolated from the rhizome of Ligusticum chuanxiong Hort. In particular, compounds 1-2, 5 were rarely phenylpropanoid phenolic acid dimers through different polymerization action in natural products. Their structures were established using UV, IR, HRESIMS, NMR data. The absolute configurations of 3 was determined by quantum ECD calculation and 4, 6-7 were determined by the ECD exciton chirality method. In addition, all compounds were evaluated for their neuroprotective effects on human neuroblastoma SH-SY5Y cell injury induced by HO. Compound 2 had a moderate neuroprotective activity and 7 had a weak neuroprotective activity on human neuroblastoma SH-SY5Y cell injury induced by HO respectively
从川芎根茎中分离得到了 4 个新的阿魏酸衍生物（1-3）和川芎醛 A（4），1 个新的二聚体（5），以及 2 个新的 8-8'木质素（6-7）。特别是化合物 1-2、5 是天然产物中通过不同聚合作用形成的罕见的苯丙素类酚酸二聚体。它们的结构通过 UV、IR、HRESIMS 和 NMR 数据确定。通过量子 ECD 计算确定了 3 的绝对构型，通过 ECD 激子手性法确定了 4、6-7 的绝对构型。此外，还评估了所有化合物对人神经母细胞瘤 SH-SY5Y 细胞 HO 诱导损伤的神经保护作用。化合物 2 对 HO 诱导的人神经母细胞瘤 SH-SY5Y 细胞损伤具有中等的神经保护活性，而 7 则具有较弱的神经保护活性。
