Guo Ziyi, Long Tianjian, Yao Jianping, Li Yamin, Xiao Lu, Chen Min
Faculty of Chinese Medicine and State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau, Macao SAR, China.
Henan University of Chinese Medicine, Zhengzhou, China.
Front Pharmacol. 2024 Apr 2;15:1337876. doi: 10.3389/fphar.2024.1337876. eCollection 2024.
Depression is a severe mental disorder that poses a significant threat to both the physical and mental wellbeing of individuals. Currently, there are various methods for treating depression, including traditional Chinese herbal formulations like Chaihu-Shugan-San (CSS), which have shown effective antidepressant effects in both clinical and animal research. This review aims to provide a comprehensive synthesis of evidence related to CSS, considering both preclinical and clinical studies, to uncover its potential multi-level, multi-pathway, and multi-target mechanisms for treating depression and identify its active ingredients. A thorough search was conducted in electronic databases, including PubMed, MEDLINE, Web of Science, Google Scholar, CNKI, and Wanfang, using keywords such as "Chaihu Shugan" and "depression" to retrieve relevant literature on CSS and its active ingredients. The review process adhered to the PRISMA guidelines. This review consolidates the mechanisms underlying antidepressant effects of CSS and its active ingredients. It emphasizes its involvement in the regulation of monoaminergic neurotransmitter systems, synaptic plasticity, and the hypothalamic-pituitary-adrenal axis, among other aspects. CSS exerts a pivotal role in treating depression through various pathways, including the monoaminergic neurotransmitter system, the hypothalamic-pituitary-adrenal axis, synaptic plasticity, inflammation, brain-derived neurotrophic factor levels, and the brain-gut axis. This review facilitates a comprehensive understanding of the current state of CSS research, fostering an in-depth exploration of the etiological mechanisms of depression and the potential discovery of novel antidepressant drugs.
抑郁症是一种严重的精神障碍，对个体的身心健康构成重大威胁。目前，治疗抑郁症有多种方法，包括柴胡疏肝散（CSS）等传统中药配方，这些配方在临床和动物研究中均显示出有效的抗抑郁作用。本综述旨在综合临床前和临床研究中与CSS相关的证据，揭示其治疗抑郁症的潜在多层次、多途径和多靶点机制，并确定其活性成分。通过在电子数据库（包括PubMed、MEDLINE、Web of Science、谷歌学术、中国知网和万方）中进行全面检索，使用“柴胡疏肝”和“抑郁症”等关键词来检索关于CSS及其活性成分的相关文献。综述过程遵循PRISMA指南。本综述总结了CSS及其活性成分抗抑郁作用的潜在机制。它强调了其在单胺能神经递质系统、突触可塑性和下丘脑-垂体-肾上腺轴等方面的调节作用。CSS通过多种途径在治疗抑郁症中发挥关键作用，包括单胺能神经递质系统、下丘脑-垂体-肾上腺轴、突触可塑性、炎症、脑源性神经营养因子水平和脑-肠轴。本综述有助于全面了解CSS的研究现状，促进对抑郁症病因机制的深入探索以及新型抗抑郁药物的潜在发现。
