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本文引用的文献

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Nutraceuticals: A paradigm of proactive medicine.营养保健品:主动医学的范例。
Eur J Pharm Sci. 2017 Jan 1;96:53-61. doi: 10.1016/j.ejps.2016.09.003. Epub 2016 Sep 7.
2
Natural Products for the Treatment of Type 2 Diabetes Mellitus.用于治疗2型糖尿病的天然产物。
Planta Med. 2015 Aug;81(12-13):975-94. doi: 10.1055/s-0035-1546131. Epub 2015 Jul 1.
3
Amelioration of oxidative stress and insulin resistance by soy isoflavones (from Glycine max) in ovariectomized Wistar rats fed with high fat diet: the molecular mechanisms.大豆异黄酮(来自大豆)对高脂饮食喂养的去卵巢Wistar大鼠氧化应激和胰岛素抵抗的改善作用:分子机制
Exp Gerontol. 2015 Mar;63:67-75. doi: 10.1016/j.exger.2015.02.001. Epub 2015 Feb 7.
4
Effect of soy isoflavone crude extract supplementation on high fat diet-induced insulin resistance in ovariectomized rats.大豆异黄酮粗提物补充剂对去卵巢大鼠高脂饮食诱导的胰岛素抵抗的影响。
Biomed Environ Sci. 2014 Jan;27(1):49-51. doi: 10.3967/bes2014.014.
5
Enhancement of glucose uptake in muscular cell by soybean charged peptides isolated by electrodialysis with ultrafiltration membranes (EDUF): activation of the AMPK pathway.电渗析超滤膜分离的大豆带电肽增强肌细胞葡萄糖摄取:AMPK 通路的激活。
Food Chem. 2014 Mar 15;147:124-30. doi: 10.1016/j.foodchem.2013.09.108. Epub 2013 Sep 26.
6
Developing fruit-based nutritious snack bars.开发基于水果的营养小吃棒。
J Sci Food Agric. 2014 Jan 15;94(1):52-6. doi: 10.1002/jsfa.6282. Epub 2013 Jul 23.
7
Protective effect of short-term genistein supplementation on the early stage in diabetes-induced renal damage.短期金雀异黄素补充对糖尿病诱导的早期肾脏损伤的保护作用。
Mediators Inflamm. 2013;2013:510212. doi: 10.1155/2013/510212. Epub 2013 Apr 29.
8
Incorporation of soybean by-product okara and inulin in a probiotic soy yoghurt: texture profile and sensory acceptance.在益生菌大豆酸奶中添加大豆副产物豆渣和菊粉:质构特性和感官接受度。
J Sci Food Agric. 2014 Jan 15;94(1):119-25. doi: 10.1002/jsfa.6212. Epub 2013 Jun 6.
9
Development and storage study of reduced sugar soy containing compound chocolate.低糖复合巧克力豆的研制与贮藏研究。
J Food Sci Technol. 2011 Feb;48(1):76-82. doi: 10.1007/s13197-010-0136-8. Epub 2010 Oct 28.
10
Prevention of diabetes in db/db mice by dietary soy is independent of isoflavone levels.饮食中的大豆可预防 db/db 小鼠的糖尿病,与异黄酮水平无关。
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富含异黄酮的新型大豆基高蛋白棒可改善糖尿病Wistar大鼠的胰岛素敏感性。

Novel soybean-based high protein bar rich in isoflavones improves insulin sensitivity in diabetic Wistar rats.

作者信息

Faria Wanessa Costa Silva, Giordani Morenna Alana, da Silva Arcas Ariadny, Cavenaghi Daniela Fernanda Lima Carvalho, de Oliveira Adriana Paiva, Dos Santos Jacqueline Fiuza, Barros Wander Miguel

机构信息

1Food Science and Technology Post-Graduate Program, Federal Institute of Education, Science and Technology of Mato Grosso (IFMT), Cuiabá Campus - Bela Vista, Av. Juliano da Costa Marques s/n, Bela Vista, Cuiabá, MT 78050-560 Brazil.

2Institute of Health Sciences, Federal University of Mato Grosso, University Campus of Sinop, Avenida Alexandre Ferronato, 1200, Setor Industrial, Sinop, MT 78557-267 Brazil.

出版信息

J Food Sci Technol. 2018 Jan;55(1):21-32. doi: 10.1007/s13197-017-2753-y. Epub 2017 Nov 4.

DOI:10.1007/s13197-017-2753-y
PMID:29358792
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5756179/
Abstract

This study assessed the effect of whey protein substitution with isolated soy protein in protein bar (PB) formulations at 25% (PB2), 50% (PB3), or 75% (PB1) weight/weight on the proximate and mineral composition, sensory, and antidiabetic properties. Sensory evaluation was conducted within diabetic (DB) and non-diabetic (NDB) consumers by preference ranking and acceptance test. The formulations were analysed in terms of moisture, ash, protein, lipid, carbohydrates, fibers and mineral content. The consumers did not distinguish the formulations by preference ranking test. However, the acceptability test showed a rating of 9 most frequent for PB1 (36.30%), followed by PB2 and PB3 (both 34.09%), among DB consumers. The PB1 and PB3 showed higher content of total, soluble and insoluble fibers and, PB 2 presented higher carbohydrate content. Potassium, sodium and calcium showed the highest mineral content in the formulations. PB3 was assessed for glycaemic and lipidemic control in diabetics and non-diabetics female Wistar rats, for this 20% of PB was added in the ration consumed ad libitum, besides, the rats received 100 mg/kg b. w. by gavage daily. The treatment did not reduce significantly fasting glucose, lipid profile, or peripheral glucose disposal in DB or NDB rats. However, it significantly improved insulin tolerance test values in diabetic rats. The results suggest that the formulations showed good acceptance and potentially ameliorate insulin resistance both in control group and in animal model of type II diabetes.

摘要

本研究评估了在蛋白棒(PB)配方中用分离大豆蛋白替代乳清蛋白,以25%(PB2)、50%(PB3)或75%(PB1)的重量/重量比例替代时,对其近似成分、矿物质组成、感官特性和抗糖尿病特性的影响。通过偏好排序和接受度测试,在糖尿病(DB)和非糖尿病(NDB)消费者中进行了感官评价。对配方的水分、灰分、蛋白质、脂质、碳水化合物、纤维和矿物质含量进行了分析。通过偏好排序测试,消费者无法区分这些配方。然而,接受度测试显示,在DB消费者中,PB1的接受度最高,为9分的频率最高(36.30%),其次是PB2和PB3(均为34.09%)。PB1和PB3的总纤维、可溶性纤维和不溶性纤维含量较高,而PB2的碳水化合物含量较高。钾、钠和钙在配方中的矿物质含量最高。对雌性Wistar糖尿病大鼠和非糖尿病大鼠评估了PB3对血糖和血脂的控制作用,为此在随意摄入的日粮中添加了20%的PB,此外,大鼠每天通过灌胃接受100mg/kg体重的剂量。该处理在DB或NDB大鼠中并未显著降低空腹血糖、血脂水平或外周葡萄糖处置。然而,它显著改善了糖尿病大鼠的胰岛素耐量测试值。结果表明,这些配方在对照组和II型糖尿病动物模型中均表现出良好的接受度,并可能改善胰岛素抵抗。