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接受贝利尤单抗治疗的患者发生类似克罗恩病的结肠炎并出现狭窄。

Stricturing Crohn's disease-like colitis in a patient treated with belatacept.

机构信息

Gastroenterology Department, Saint-Eloi Hospital, Montpellier University Hospital, Montpellier 34000, France.

Nephrology Department, Lapeyronie Hospital, Montpellier University Hospital, Montpellier 34000, France.

出版信息

World J Gastroenterol. 2017 Dec 28;23(48):8660-8665. doi: 10.3748/wjg.v23.i48.8660.

DOI:10.3748/wjg.v23.i48.8660
PMID:29358873
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5752725/
Abstract

Cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) modifying agents have been involved in the development of intestinal inflammation, especially therapeutic monoclonal antibodies directed against CTLA-4. Here we report the appearance of a severe stricturing Crohn's disease-like colitis in a patient with a kidney allograft who was treated with belatacept, a recombinant CTLA-4-Ig fusion protein.

摘要

细胞毒性 T 淋巴细胞相关抗原 4（CTLA-4）修饰剂与肠道炎症的发生有关，特别是针对 CTLA-4 的治疗性单克隆抗体。在这里，我们报告了一名接受 belatacept（一种 CTLA-4-Ig 融合蛋白）治疗的肾移植患者出现严重的狭窄性克罗恩病样结肠炎。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/172a/5752725/fff125887e98/WJG-23-8660-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/172a/5752725/2f36af87b04c/WJG-23-8660-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/172a/5752725/fff125887e98/WJG-23-8660-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/172a/5752725/2f36af87b04c/WJG-23-8660-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/172a/5752725/fff125887e98/WJG-23-8660-g002.jpg

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Ann Oncol. 2017 Jun 1;28(6):1368-1379. doi: 10.1093/annonc/mdx108.
2
Safety and Efficacy Outcomes 3 Years After Switching to Belatacept From a Calcineurin Inhibitor in Kidney Transplant Recipients: Results From a Phase 2 Randomized Trial.在肾移植受者中从钙调磷酸酶抑制剂转换至贝利尤单抗后的 3 年安全性和疗效结局：一项 2 期随机试验的结果。
Am J Kidney Dis. 2017 May;69(5):587-594. doi: 10.1053/j.ajkd.2016.09.021. Epub 2016 Nov 23.
3
Cancer Immunotherapy with Anti-CTLA-4 Monoclonal Antibodies Induces an Inflammatory Bowel Disease.
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J Crohns Colitis. 2016 Apr;10(4):395-401. doi: 10.1093/ecco-jcc/jjv227. Epub 2016 Jan 18.
4
Endoscopic and histological features of mycophenolate mofetil colitis in patients after solid organ transplantation.实体器官移植术后患者霉酚酸酯结肠炎的内镜及组织学特征
Ann Gastroenterol. 2015 Jul-Sep;28(3):366-373.
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Two cases of ulcerative colitis developing in rheumatoid arthritis patients during abatacept therapy.
Scand J Gastroenterol. 2014 Oct;49(10):1270-1. doi: 10.3109/00365521.2014.946087. Epub 2014 Aug 13.
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