接受贝利尤单抗治疗的患者发生类似克罗恩病的结肠炎并出现狭窄。
Stricturing Crohn's disease-like colitis in a patient treated with belatacept.
机构信息
Gastroenterology Department, Saint-Eloi Hospital, Montpellier University Hospital, Montpellier 34000, France.
Nephrology Department, Lapeyronie Hospital, Montpellier University Hospital, Montpellier 34000, France.
出版信息
World J Gastroenterol. 2017 Dec 28;23(48):8660-8665. doi: 10.3748/wjg.v23.i48.8660.
Abstract
Cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) modifying agents have been involved in the development of intestinal inflammation, especially therapeutic monoclonal antibodies directed against CTLA-4. Here we report the appearance of a severe stricturing Crohn's disease-like colitis in a patient with a kidney allograft who was treated with belatacept, a recombinant CTLA-4-Ig fusion protein.
摘要
细胞毒性 T 淋巴细胞相关抗原 4（CTLA-4）修饰剂与肠道炎症的发生有关，特别是针对 CTLA-4 的治疗性单克隆抗体。在这里，我们报告了一名接受 belatacept（一种 CTLA-4-Ig 融合蛋白）治疗的肾移植患者出现严重的狭窄性克罗恩病样结肠炎。
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