Wang Zhiyong, Wang Jianwei, Qin Lihua, Zhang Weiguang
Department of Anatomy and Histo-Embryology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.
Key Lab for Neuroscience, Ministry of Education/National Health and Family Planning Commission of China, Peking University, Beijing 100191, China.
Evid Based Complement Alternat Med. 2017;2017:8197281. doi: 10.1155/2017/8197281. Epub 2017 Dec 5.
Neuropathic pain is common in clinical practice. Exploration of new drug therapeutics has always been carried out for more satisfactory effects and fewer side-effects. In the present study, we aimed to investigate effects of Tongluo Zhitong Prescription (TZP), a compounded Chinese medicine description, on neuropathic pain model of rats with chronic constriction injury (CCI). The CCI model was established by loosely ligating sciatic nerve with catgut suture, proximal to its trifurcation. The static and dynamic allodynia, heat hyperalgesia, mechanical allodynia, cold allodynia, and gait were assessed. Our results showed that TZP alleviated CCI-induced static and dynamic allodynia, suppressed heat hyperalgesia and cold and mechanical allodynia, and improved gait function. These results suggest that TZP could alleviate neuropathic pain. Further experiments are needed to explore its mechanisms.
神经病理性疼痛在临床实践中很常见。人们一直在探索新的药物治疗方法，以获得更满意的效果和更少的副作用。在本研究中，我们旨在研究通络止痛方（TZP），一种复方中药制剂，对慢性压迫性损伤（CCI）大鼠神经病理性疼痛模型的影响。通过在坐骨神经三叉近端用肠线松散结扎建立CCI模型。评估静态和动态痛觉过敏、热痛觉过敏、机械性痛觉过敏、冷痛觉过敏和步态。我们的结果表明，TZP减轻了CCI诱导的静态和动态痛觉过敏，抑制了热痛觉过敏、冷和机械性痛觉过敏，并改善了步态功能。这些结果表明，TZP可以减轻神经病理性疼痛。需要进一步的实验来探索其机制。
