Tippett Donna C, Godin Brittany R, Oishi Kumiko, Oishi Kenichi, Davis Cameron, Gomez Yessenia, Trupe Lydia A, Kim Eun Hye, Hillis Argye E
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore Maryland.
Department of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, Baltimore Maryland.
Semin Speech Lang. 2018 Feb;39(1):87-100. doi: 10.1055/s-0037-1608859. Epub 2018 Jan 22.
Despite its basic and translational importance, the neural circuitry supporting the perception of emotional faces remains incompletely understood. Functional imaging studies and chronic lesion studies indicate distinct roles of the amygdala and insula in recognition of fear and disgust in facial expressions, whereas intracranial encephalography studies, which are not encumbered by variations in human anatomy, indicate a somewhat different role of these structures. In this article, we leveraged lesion-mapping techniques in individuals with right hemisphere stroke to investigate lesions associated with impaired recognition of prototypic emotional faces before significant neural reorganization can occur during recovery from stroke. Right hemisphere stroke patients were significantly less accurate than controls on a test of emotional facial recognition for both positive and negative emotions. Patients with right amygdala or anterior insula lesions had significantly lower scores than other right hemisphere stroke patients on recognition of angry and happy faces. Lesion volume within several regions, including the right amygdala and anterior insula, each independently contributed to the error rate in recognition of individual emotions. Results provide additional support for a necessary role of the right amygdala and anterior insula within a network of regions underlying recognition of facial expressions, particularly those that have biological importance or motivational relevance and have implications for clinical practice.
尽管其具有基础和转化意义，但支持对面部表情进行情感感知的神经回路仍未被完全理解。功能成像研究和慢性损伤研究表明杏仁核和脑岛在识别面部表情中的恐惧和厌恶方面具有不同作用，而不受人体解剖结构变异影响的颅内脑电描记术研究则表明这些结构的作用有所不同。在本文中，我们利用右半球中风患者的损伤映射技术，研究在中风恢复过程中发生显著神经重组之前，与原型情感面部识别受损相关的损伤。在一项针对正面和负面情绪的情感面部识别测试中，右半球中风患者的准确性明显低于对照组。右杏仁核或前脑岛损伤的患者在识别愤怒和高兴的面部表情时，得分明显低于其他右半球中风患者。包括右杏仁核和前脑岛在内的几个区域的损伤体积，各自独立地导致了个体情绪识别中的错误率。研究结果为右杏仁核和前脑岛在面部表情识别基础区域网络中的必要作用提供了额外支持，尤其是那些具有生物学重要性或动机相关性的表情，并且对临床实践具有启示意义。
