Burnett J C, Kao P C, Hu D C, Heser D W, Heublein D, Granger J P, Opgenorth T J, Reeder G S
Science. 1986 Mar 7;231(4742):1145-7. doi: 10.1126/science.2935937.
A sensitive radioimmunoassay for atrial natriuretic peptide was used to examine the relation between circulating atrial natriuretic peptide and cardiac filling pressure in normal human subjects, in patients with cardiovascular disease and normal cardiac filling pressure, and in patients with cardiovascular disease and elevated cardiac filling pressure with and without congestive heart failure. The present studies establish a normal range for atrial natriuretic peptide in normal human subjects. These studies also establish that elevated cardiac filling pressure is associated with increased circulating concentrations of atrial natriuretic peptide and that congestive heart failure is not characterized by a deficiency in atrial natriuretic peptide, but with its elevation.
采用一种灵敏的心房利钠肽放射免疫分析法，研究正常受试者、心血管疾病且心脏充盈压正常的患者以及心血管疾病且心脏充盈压升高伴或不伴有充血性心力衰竭的患者，其循环中的心房利钠肽与心脏充盈压之间的关系。本研究确定了正常受试者心房利钠肽的正常范围。这些研究还证实，心脏充盈压升高与循环中心房利钠肽浓度增加相关，且充血性心力衰竭的特征并非心房利钠肽缺乏，而是其升高。
