孕32周及以下早产儿的生长与身体组成：队列研究

Growth and body composition of preterm infants less than or equal to 32 weeks: Cohort study.

作者信息

Villela Letícia Duarte, Méio Maria Dalva Barbosa Baker, de Matos Fonseca Vânia, de Abranches Andrea Dunshee, Junior Saint-Clair Gomes, da Costa Ana Carolina Carioca, Murta Maria M, Nehab Sylvia Reis Gonçalves, Soares Fernanda Valente Mendes, Moreira Maria Elisabeth Lopes

机构信息

Instituto Fernandes Figueira (IFF/Fiocruz), Brazil.

出版信息

Early Hum Dev. 2018 Feb;117:90-95. doi: 10.1016/j.earlhumdev.2018.01.007. Epub 2018 Jan 23.

DOI:10.1016/j.earlhumdev.2018.01.007

PMID:29360048

Abstract

BACKGROUND

Extremely preterm infants with weights less than the 10th percentile at discharge have a fat-free mass deficit.

AIM

To analyze the relationship of weight Z-scores less than -2SD at term age with fat-free mass and fat mass at term age and at 1 and 3 months of corrected age in very preterm infants.

STUDY DESIGN

COHORT STUDY: Subjects: Sixty-six preterm infants born before or at 32 weeks gestation with birth weight equal or greater than the 10th percentile for age were included at term age. They were classified according to weight Z-score as either: "term (-)" (n = 18) if weight Z-scores were less -2SD or "term (+)" (n = 48) if the weight Z-scores were equal or greater than -2SD at term age.

OUTCOME MEASURES

Growth and body composition by an air displacement plethysmography system and bioimpedance were assessed at term age and 1 and 3 months of corrected age.

RESULTS

Lower fat-free mass persisted up to 3 months in the "term (-)" group [4137 g (645) vs 4592 g (707), p < .01]. Fat mass was lower in the "term (-)" group at term and at 1 month but was similar at 3 months of corrected age [1295 g (774) vs 1477 g (782), p = .109]. Weight, length and head circumference Z-scores were lower in the "term (-)" group compared to those in the "term (+)" group.

CONCLUSIONS

The lean tissue deficits were maintained in the "term (-)" group while the differences in body fat percentage were not.

摘要

背景

出院时体重低于第10百分位数的极早产儿存在去脂体重不足。

目的

分析极早产儿足月时体重Z评分低于-2SD与足月时、矫正年龄1个月和3个月时的去脂体重及脂肪量之间的关系。

研究设计

队列研究：研究对象：纳入66例孕32周及以前出生、出生体重等于或大于同年龄第10百分位数的早产儿，在足月时进行研究。根据体重Z评分将他们分为：“足月（-）”组（n = 18），如果足月时体重Z评分低于-2SD；或“足月（+）”组（n = 48），如果足月时体重Z评分等于或高于-2SD。

观察指标

在足月时、矫正年龄1个月和3个月时，采用空气置换体积描记系统和生物电阻抗评估生长情况和身体成分。

结果

“足月（-）”组的较低去脂体重持续至3个月[4137 g（645）vs 4592 g（707），p <.01]。“足月（-）”组在足月时和1个月时的脂肪量较低，但在矫正年龄3个月时相似[1295 g（774）vs 1477 g（782），p =.109]。“足月（-）”组的体重、身长和头围Z评分低于“足月（+）”组。