Department of Pathology and Immunology, Washington University School of Medicine, USA.
Department of Pathology and Microbiology, Saga University, Japan.
Hepatology. 2018 Jul;68(1):113-126. doi: 10.1002/hep.29789. Epub 2018 May 9.
Primary liver carcinomas with both hepatocytic and cholangiocytic differentiation have been referred to as "combined (or mixed) hepatocellular-cholangiocarcinoma." These tumors, although described over 100 years ago, have attracted greater attention recently because of interest in possible stem cell origin and perhaps because of greater frequency and clinical recognition. Currently, because of a lack of common terminology in the literature, effective treatment and predictable outcome data have been challenging to accrue. This article represents a consensus document from an international community of pathologists, radiologists, and clinicians who have studied and reported on these tumors and recommends a working terminology for diagnostic and research approaches for further study and evaluation.
It is recommended that diagnosis is based on routine histopathology with hematoxylin and eosin (H&E); immunostains are supportive, but not essential for diagnosis. (Hepatology 2018;68:113-126).
既有肝细胞又有胆管细胞分化的原发性肝癌被称为“混合型（或混合性）肝细胞-胆管细胞癌”。这些肿瘤虽然在 100 多年前就已被描述，但由于对可能的干细胞起源的关注以及可能由于更常见和临床识别度的提高，最近引起了更多关注。目前，由于文献中缺乏通用术语，有效治疗和可预测的结果数据的积累一直具有挑战性。本文代表了一个国际病理学家、放射科医生和临床医生的共识文件，他们研究并报告了这些肿瘤，并为进一步研究和评估推荐了用于诊断和研究方法的工作术语。
建议基于常规组织病理学检查，使用苏木精和伊红（H&E）染色；免疫组化染色是支持性的，但不是诊断所必需的。（《肝脏病学》2018；68：113-126）。
