Vertii Anastassiia, Kaufman Paul D, Hehnly Heidi, Doxsey Stephen
Department of Molecular, Cell and Cancer Biology University of Massachusetts Medical School, Worcester, Massachusetts.
Department of Cell and Developmental Biology, SUNY Upstate Medical University, Syracuse, New York, 13210.
Cytoskeleton (Hoboken). 2018 Mar;75(3):87-102. doi: 10.1002/cm.21434. Epub 2018 Feb 8.
Traditionally, we imagine that cell division gives rise to two identical daughter cells. Nevertheless, all cell divisions, to some degree, display asymmetry. Asymmetric cell division is defined as the generation of two daughter cells with different physical content and/or developmental potential. Several organelles and cellular components including the centrosome, non-coding RNA, chromatin, and recycling endosomes are involved in the process of asymmetric cell division. Disruption of this important process is known to induce profound defects in development, the immune response, regeneration of tissues, aging, and cancer. Here, we discuss recent advances that expand our understanding of the mechanisms and consequences of asymmetric cell division in vertebrate organisms.
传统上，我们认为细胞分裂会产生两个完全相同的子细胞。然而，所有的细胞分裂在某种程度上都表现出不对称性。不对称细胞分裂被定义为产生两个具有不同物质内容和/或发育潜能的子细胞。包括中心体、非编码RNA、染色质和循环内体在内的几种细胞器和细胞成分参与了不对称细胞分裂过程。已知这一重要过程的破坏会在发育、免疫反应、组织再生、衰老和癌症中引发严重缺陷。在这里，我们讨论了最近的进展，这些进展扩展了我们对脊椎动物中不对称细胞分裂的机制和后果的理解。
