Life Sciences Institute, Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.
Whitehead Institute for Biomedical Research, Department of Biology, Massachusetts Institute of Technology, Howard Hughes Medical Institute, Cambridge, MA, USA.
Open Biol. 2021 Jan;11(1):200314. doi: 10.1098/rsob.200314. Epub 2021 Jan 13.
The centrosome is a unique organelle: the semi-conservative nature of its duplication generates an inherent asymmetry between 'mother' and 'daughter' centrosomes, which differ in their age. This asymmetry has captivated many cell biologists, but its meaning has remained enigmatic. In the last two decades, many stem cell types have been shown to display stereotypical inheritance of either the mother or daughter centrosome. These observations have led to speculation that the mother and daughter centrosomes bear distinct information, contributing to differential cell fates during asymmetric cell divisions. This review summarizes recent progress and discusses how centrosome asymmetry may promote asymmetric fates during stem cell divisions.
其复制的半保守性质在“母”和“子”中心体之间产生了固有的不对称性，它们在年龄上有所不同。这种不对称性吸引了许多细胞生物学家，但它的意义仍然是神秘的。在过去的二十年中，已经显示出许多干细胞类型表现出母或子中心体的典型遗传。这些观察结果导致了这样的推测，即母和子中心体承载着不同的信息，有助于不对称细胞分裂期间的不同细胞命运。本综述总结了最近的进展，并讨论了中心体不对称性如何在干细胞分裂期间促进不对称命运。
