Rajizadeh Mohammad Amin, Esmaeilpour Khadijeh, Masoumi-Ardakani Yaser, Bejeshk Mohammad Abbas, Shabani Mohammad, Nakhaee Nouzar, Ranjbar Mohammad Pour, Borzadaran Fatemeh Mohtashami, Sheibani Vahid
Department of Physiology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran; Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
Physiol Behav. 2018 May 1;188:58-66. doi: 10.1016/j.physbeh.2017.12.030. Epub 2018 Jan 31.
Sleep loss is a common problem in modern societies affecting different aspects of individuals' lives. Many studies have reported that sleep deprivation (SD) leads to impairments in various types of learning and memory. Physical exercise has been suggested to attenuate the cognitive impairments induced by sleep deprivation in male rats. Our previous studies have shown that forced exercise by treadmill improved learning and memory impairments following SD. The aim of the current study was to investigate the effects of voluntary exercise by running wheel on cognitive, motor and anxiety-like behavior functions of female rats following 72 h SD. Intact female rats were used in the present study. The multiple platform method was applied for the induction of 72 h SD. The exercise protocol was 4 weeks of running wheel and the cognitive function was evaluated using Morris water maze (MWM), passive avoidance and novel object recognition tests. Open field test and measurement of plasma corticosterone level were performed for evaluation of anxiety-like behaviors. Motor balance evaluation was surveyed by rotarod test. In this study, remarkable learning and long-term memory impairments were observed in sleep deprived rats in comparison to the other groups. Running wheel exercise ameliorated the SD-induced learning and memory impairments. Voluntary and mandatory locomotion and balance situation were not statistically significant among the different groups. Our study confirmed the negative effects of SD on cognitive function and approved protective effects of voluntary exercise on these negative effects.
睡眠不足是现代社会中的一个常见问题，影响着个人生活的方方面面。许多研究报告称，睡眠剥夺（SD）会导致各种类型的学习和记忆受损。有研究表明，体育锻炼可以减轻雄性大鼠睡眠剥夺引起的认知障碍。我们之前的研究表明，通过跑步机进行强迫运动可改善睡眠剥夺后的学习和记忆障碍。本研究的目的是调查在72小时睡眠剥夺后，通过跑轮进行自愿运动对雌性大鼠认知、运动和焦虑样行为功能的影响。本研究使用了未受影响的雌性大鼠。采用多平台方法诱导72小时睡眠剥夺。运动方案为进行4周的跑轮运动，并使用莫里斯水迷宫（MWM）、被动回避和新物体识别测试来评估认知功能。通过旷场试验和测量血浆皮质酮水平来评估焦虑样行为。通过转棒试验来评估运动平衡。在本研究中，与其他组相比，睡眠剥夺大鼠出现了明显的学习和长期记忆障碍。跑轮运动改善了睡眠剥夺引起的学习和记忆障碍。不同组之间的自愿和强制运动及平衡情况在统计学上无显著差异。我们的研究证实了睡眠剥夺对认知功能的负面影响，并认可了自愿运动对这些负面影响的保护作用。
