Department of Food and Drug, University of Parma, 43124 Parma, Italy.
Toxins (Basel). 2018 Jan 23;10(2):52. doi: 10.3390/toxins10020052.
Mycotoxins severely threaten the health of humans and animals. For this reason, many countries have enforced regulations and recommendations to reduce the dietary exposure. However, even though regulatory actions must be based on solid scientific knowledge, many aspects of their toxicological activity are still poorly understood. In particular, deepening knowledge on the primal molecular events triggering the toxic stimulus may be relevant to better understand the mechanisms of action of mycotoxins. The present work presents the use of in silico approaches in studying the mycotoxins toxicodynamics, and discusses how they may contribute in widening the background of knowledge. A particular emphasis has been posed on the methods accounting the molecular initiating events of toxic action. In more details, the key concepts and challenges of mycotoxins toxicology have been introduced. Then, topical case studies have been presented and some possible practical implementations of studying mycotoxins toxicodynamics have been discussed.
真菌毒素严重威胁着人类和动物的健康。出于这个原因，许多国家已经制定了法规和建议来减少饮食中的暴露。然而，尽管监管行动必须基于坚实的科学知识，但它们的许多毒理学活性方面仍未得到很好的理解。特别是，加深对触发毒性刺激的原始分子事件的了解，可能有助于更好地理解真菌毒素的作用机制。本工作介绍了使用计算方法研究真菌毒素毒代动力学，并讨论了它们如何有助于扩大知识背景。特别强调了考虑毒性作用分子起始事件的方法。更详细地说，介绍了真菌毒素毒理学的关键概念和挑战。然后，提出了一些主题案例研究，并讨论了研究真菌毒素毒代动力学的一些可能的实际应用。
