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随机对照试验中机器人辅助腹腔镜手术与传统腹腔镜手术的系统评价和荟萃分析

Robot-assisted laparoscopic surgery versus conventional laparoscopic surgery in randomized controlled trials: A systematic review and meta-analysis.

作者信息

Roh Hyunsuk Frank, Nam Seung Hyuk, Kim Jung Mogg

机构信息

Department of Biomedical Science, Hanyang University College of Medicine and Graduate School of Biomedical Science and Engineering, Seoul, Korea.

Department of Microbiology and Biomedical Science, Hanyang University College of Medicine and Graduate School of Biomedical Science and Engineering, Seoul, Korea.

出版信息

PLoS One. 2018 Jan 23;13(1):e0191628. doi: 10.1371/journal.pone.0191628. eCollection 2018.

Abstract

IMPORTANCE

This review provides a comprehensive comparison of treatment outcomes between robot-assisted laparoscopic surgery (RLS) and conventional laparoscopic surgery (CLS) based on randomly-controlled trials (RCTs).

OBJECTIVES

We employed RCTs to provide a systematic review that will enable the relevant community to weigh the effectiveness and efficacy of surgical robotics in controversial fields on surgical procedures both overall and on each individual surgical procedure.

EVIDENCE REVIEW

A search was conducted for RCTs in PubMed, EMBASE, and Cochrane databases from 1981 to 2016. Among a total of 1,517 articles, 27 clinical reports with a mean sample size of 65 patients per report (32.7 patients who underwent RLS and 32.5 who underwent CLS), met the inclusion criteria.

FINDINGS

CLS shows significant advantages in total operative time, net operative time, total complication rate, and operative cost (p < 0.05 in all cases), whereas the estimated blood loss was less in RLS (p < 0.05). As subgroup analyses, conversion rate on colectomy and length of hospital stay on hysterectomy statistically favors RLS (p < 0.05).

CONCLUSIONS

Despite higher operative cost, RLS does not result in statistically better treatment outcomes, with the exception of lower estimated blood loss. Operative time and total complication rate are significantly more favorable with CLS.

摘要

重要性

本综述基于随机对照试验(RCT),对机器人辅助腹腔镜手术(RLS)和传统腹腔镜手术(CLS)的治疗结果进行了全面比较。

目的

我们采用随机对照试验进行系统综述,以使相关群体能够权衡手术机器人技术在有争议的手术领域中,在整体手术程序以及每个单独手术程序上的有效性和功效。

证据综述

在1981年至2016年期间,在PubMed、EMBASE和Cochrane数据库中检索随机对照试验。在总共1517篇文章中,有27篇临床报告符合纳入标准,每份报告的平均样本量为65例患者(32.7例接受RLS,32.5例接受CLS)。

研究结果

CLS在总手术时间、净手术时间、总并发症发生率和手术成本方面显示出显著优势(所有情况均p<0.05),而RLS的估计失血量较少(p<0.05)。作为亚组分析,结肠切除术的转换率和子宫切除术的住院时间在统计学上有利于RLS(p<0.05)。

结论

尽管手术成本较高,但除估计失血量较低外,RLS并未在统计学上带来更好的治疗结果。CLS的手术时间和总并发症发生率明显更有利。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a8e/5779699/9f105998a8fb/pone.0191628.g001.jpg

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