Center for Crohn's and Colitis, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Harvard Medical School, Harvard University, Boston, Massachusetts, USA.
Inflamm Bowel Dis. 2018 Jan 18;24(2):310-316. doi: 10.1093/ibd/izx053.
Men with inflammatory bowel disease (IBD) may have increased sexual dysfunction. To measure the prevalence of sexual dysfunction in our male patients, we aimed to develop a new IBD-specific Male Sexual Dysfunction Scale (the IBD-MSDS).
We used a cross-sectional survey and enrolled male patients (N = 175) ≥18 years old who attended IBD clinics at 2 Boston hospitals. We collected information on sexual functioning via a 15-item scale. General male sexual functioning was measured using the International Index of Erectile Dysfunction (IIEF); the Patient Health Questionnaire (PHQ-9) measured depressive symptoms. Medical history and sociodemographic information were extracted from medical record review. Exploratory factor analyses (EFA) assessed unidimensionality, factor structure, reliability, and criterion and construct validity of the 15-item scale. We used regression models to identify clinical factors associated with sexual dysfunction.
EFA suggested retaining 10-items generating a unidimensional scale with strong internal consistency reliability, α = 0.90. Criterion validity assessed using Spearman's coefficient showing that the IBD-MSDS was significantly correlated with all the subscales of the IIEF. The IBD-MSDS was significantly correlated (construct validity) with the PHQ-9 (P < 0.001) and the composite score for active IBD cases (P < 0.05). Male sexual dysfunction in IBD was significantly associated with the presence of an ileoanal pouch anastomosis (P = 0.047), depression (P < 0.001), and increased disease activity (P = 0.021).
We have developed and validated an IBD-specific scale to assess the psychosexual impact of IBD. This new survey tool may help physicians screen for and identify factors contributing to impaired sexual functioning in their male patients.
患有炎症性肠病（IBD）的男性可能存在性功能障碍。为了评估我们男性患者性功能障碍的患病率，我们旨在开发一种新的 IBD 特异性男性性功能障碍量表（IBD-MSDS）。
我们采用横断面调查，纳入了 2 家波士顿医院 IBD 诊所≥18 岁的男性患者（N=175）。我们通过 15 项量表收集了性功能相关信息。国际勃起功能指数（IIEF）用于评估男性一般性功能；患者健康问卷（PHQ-9）评估抑郁症状。从病历回顾中提取了病史和社会人口学信息。探索性因子分析（EFA）评估了 15 项量表的维度性、结构、可靠性、效标和结构效度。我们使用回归模型来确定与性功能障碍相关的临床因素。
EFA 提示保留 10 项可产生具有强内部一致性信度（α=0.90）的单一维度量表。使用 Spearman 系数评估效标效度，结果表明 IBD-MSDS 与 IIEF 的所有亚量表显著相关。IBD-MSDS 与 PHQ-9（P<0.001）和活动 IBD 病例的综合评分（P<0.05）显著相关（结构效度）。IBD 男性性功能障碍与回肠肛门吻合术（P=0.047）、抑郁（P<0.001）和疾病活动度增加（P=0.021）显著相关。
我们开发并验证了一种 IBD 特异性量表来评估 IBD 对心理性的影响。这种新的调查工具可以帮助医生筛查和识别导致男性患者性功能障碍的因素。
