Brigham and Women's Hospital, Boston, Massachusetts.
Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts.
Inflamm Bowel Dis. 2018 Oct 12;24(11):2350-2359. doi: 10.1093/ibd/izy202.
Women with inflammatory bowel disease (IBD) may have decreased sexual function. To understand how common this condition is in our female patients, we developed a new IBD-specific Female Sexual Dysfunction Scale (the IBD-FSDS).
We performed a prospective cross-sectional study of 454 female IBD patients ≥18 years of age attending 1 of 3 IBD clinics in the United States or Denmark. We gathered information on sexual function via a de novo 23-item scale. General sexual functioning was measured with the Female Sexual Function Index (FSFI) and the Female Sexual Distress Scale-Revised (FSDS-R). Depressive symptoms were measured with the Patient Health Questionnaire-9 (PHQ-9). Medical history and sociodemographic data were collected via chart review. Exploratory factor analyses (EFAs) of the English language version of IBD-FSDS assessed unidimensionality, factor structure, reliability, criterion validity, and construct validity.
EFAs suggested retaining 15-items creating a unidimensional scale with strong internal consistency reliability (α = 0.93). Validity of the English language IBD-FSDS was measured using Spearman's coefficient, demonstrating significant criterion validity with the FSDS-R (P < 0.05) and the FSFI (P < 0.05) and significant construct validity with the composite for cases of active IBD (P < 0.05) and PHQ-9 (P < 0.05). Sexual dysfunction in women with IBD was significantly associated with depression (P = 0.042), active IBD (P = 0.002), and no history of surgery (P = 0.044).
We have developed and validated an IBD-specific scale to assess the psychosexual impact of IBD in women. This novel screening questionnaire may help health care providers recognize factors contributing to impaired sexual function in their female patients.
患有炎症性肠病（IBD）的女性可能会出现性功能下降。为了了解这种情况在我们的女性患者中有多常见，我们开发了一种新的 IBD 特异性女性性功能障碍量表（IBD-FSDS）。
我们对美国或丹麦的 3 个 IBD 诊所的 454 名年龄≥18 岁的女性 IBD 患者进行了前瞻性横断面研究。我们通过一个新的 23 项量表收集性功能信息。女性性功能的一般情况通过女性性功能指数（FSFI）和女性性功能障碍修订版（FSDS-R）进行测量。抑郁症状通过患者健康问卷-9（PHQ-9）进行测量。通过病历回顾收集医学史和社会人口统计学数据。IBD-FSDS 英文版本的探索性因素分析（EFA）评估了单维性、结构、可靠性、标准有效性和构念有效性。
EFA 建议保留 15 项，创建一个具有强内部一致性可靠性（α=0.93）的单维量表。使用 Spearman 系数测量了英文 IBD-FSDS 的有效性，表明与 FSDS-R（P < 0.05）和 FSFI（P < 0.05）具有显著的标准有效性，与活跃 IBD 的综合情况（P < 0.05）和 PHQ-9（P < 0.05）具有显著的构念有效性。IBD 女性的性功能障碍与抑郁（P=0.042）、活跃 IBD（P=0.002）和无手术史（P=0.044）显著相关。
我们开发并验证了一种用于评估 IBD 对女性心理性影响的 IBD 特异性量表。这种新的筛选问卷可能有助于医疗保健提供者识别导致女性患者性功能障碍的因素。
