Hädge D
Allerg Immunol (Leipz). 1985;31(4):231-43.
Review. All vertebrates, so far tested, possess immunoglobulins of IgM class similar to the IgM of mammals in structure and function. On the phylogenetic level of anuran amphibians a low-molecular weight 7S immunglobulin type appears occurring in the representatives of reptiles and birds, too. These 7S immunoglobulins (earlier called IgY-like immunoglobulins) show physico-chemical and antigenic properties common to the mammalian IgA. Therefore, they can be considered the precursors of mammalian IgA. The immunoglobulins of IgG, IgD, and IgE classes represent phylogenetically modern molecules appearing during the evolution on the level of mammals. Besides, some special developments can be observed amongst the immunoglobulins.
综述。迄今为止所测试的所有脊椎动物都拥有IgM类免疫球蛋白，其结构和功能与哺乳动物的IgM相似。在无尾两栖动物的系统发育水平上，一种低分子量的7S免疫球蛋白类型也出现在爬行动物和鸟类的代表中。这些7S免疫球蛋白（早期称为IgY样免疫球蛋白）表现出与哺乳动物IgA共有的物理化学和抗原特性。因此，它们可被视为哺乳动物IgA的前体。IgG、IgD和IgE类免疫球蛋白代表了在哺乳动物进化水平上出现的系统发育上现代的分子。此外，在免疫球蛋白中还可观察到一些特殊的发展情况。
