Hädge D, Ambrosius H
Mol Immunol. 1984 Aug;21(8):699-707. doi: 10.1016/0161-5890(84)90022-1.
Radioimmunochemical studies on the comparison of the immunological cross-reactivity between the 7-S Igs of birds, reptiles and amphibians (IgY-like Igs) and the IgA of mammals (man and pig) using 125I-chicken IgY and anti-chicken IgY(Fc) or anti-chicken IgY(H) antibodies from rabbits and carp for the detection led to the conclusion that there are close antigenic relationships between them. Therefore, the IgY-like Igs seem to be the precursors for the IgA class of mammals. From that, we give a phylogenetic tree of Igs in accordance with the evolutionary development of vertebrates.
利用¹²⁵I标记的鸡IgY以及来自兔和鲤鱼的抗鸡IgY（Fc）或抗鸡IgY（H）抗体，对鸟类、爬行动物和两栖动物的7-S免疫球蛋白（IgY样免疫球蛋白）与哺乳动物（人和猪）的IgA之间的免疫交叉反应性进行比较的放射免疫化学研究得出结论，它们之间存在密切的抗原关系。因此，IgY样免疫球蛋白似乎是哺乳动物IgA类的前体。据此，我们根据脊椎动物的进化发展给出了免疫球蛋白的系统发育树。
