降钙素原在腹腔内感染治疗中的预测作用
The Predictive Role of Procalcitonin On the Treatment of Intra-Abdominal Infections.
作者信息
Mahmutaj Dafina, Krasniqi Shaip, Braha Bedri, Limani Dalip, Neziri Burim
机构信息
Clinic of Surgery, University Clinical Center of Kosovo, Hospital and University Clinical Service of Kosovo, Prishtina, Kosovo.
Faculty of Medicine, University of Prishtina "Hasan Prishtina", Prishtina, Kosovo.
出版信息
Open Access Maced J Med Sci. 2017 Nov 24;5(7):909-914. doi: 10.3889/oamjms.2017.194. eCollection 2017 Dec 15.
AIM
This study aims to evaluate the algorithm of procalcitonin (PCT) and its role on the duration of antibiotics prescription for intra-abdominal infections.
MATERIALS AND METHODS
This study is a prospective controlled study that is conducted in groups of 50 hospitalised patients and 50 controlled group patients.
RESULTS
The results indicated that the average duration of antibiotic delivery to the PCT group was -10.6 days (SD ± 6.6 days), while in the control group -13.2 days (SD ± 4.2 days). These data showed a significant difference in the duration of antibiotic therapy and the monitoring role of PCTs in the prediction success of antibiotic treatment. The antibiotic delivery was longer in the septic shock 17 (SD ± 11.7) that corresponds to high PCT values of 67.8 (SD ± 50.9). Recurrence of the infection after the cessation of antibiotics occurred in 2 cases (4%) in the standard group, while it occurred in 3 cases (6%) in the control group.
CONCLUSION
The treatment of the intra-abdominal infections based on the PCT algorithm shortens the duration of antibiotic treatment and does not pose a risk for the recurrence of the infection.
目的
本研究旨在评估降钙素原（PCT）算法及其在腹腔内感染抗生素处方持续时间方面的作用。
材料与方法
本研究是一项前瞻性对照研究，将50例住院患者分为一组，50例对照组患者分为另一组。
结果
结果表明，PCT组抗生素给药的平均持续时间为-10.6天（标准差±6.6天），而对照组为-13.2天（标准差±4.2天）。这些数据显示抗生素治疗持续时间以及PCT在抗生素治疗预测成功中的监测作用存在显著差异。脓毒性休克患者的抗生素给药时间更长，为17天（标准差±11.7），对应的PCT值较高，为67.8（标准差±50.9）。标准组2例（4%）患者在抗生素停用后出现感染复发，而对照组有3例（6%）出现感染复发。
结论
基于PCT算法治疗腹腔内感染可缩短抗生素治疗持续时间，且不会增加感染复发风险。
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