Siregar Radha, Purnama Sri, Lakswinar Salia
Haji Adam Malik General Hospital, Dermatology and Venereology, Medan, Indonesia.
Open Access Maced J Med Sci. 2017 Dec 5;5(7):945-947. doi: 10.3889/oamjms.2017.178. eCollection 2017 Dec 15.
One of the treatments for leukaemia is chemotherapy. Side effects and toxicity of this treatment can be seen on the skin, adnexal, and mucous membranes. They might increase potential hydrogen (pH) value on the skin surface, therefore, disrupting epidermal barrier defences.
To describe the pH of the skin in children with leukaemia who received chemotherapy.
This study was an observational descriptive, cross-sectional study, conducted from March until December 2016 with 32 children with leukaemia who treated at Haji Adam Malik General Hospital, Medan as subjects. Skin pH was measured by a pH meter.
We found mean skin pH in ALL (6.28 ± 0.58), CML (5.9 ± 0) and AML (6.5 ± 0.50). The mean skin pH after 1-5 weeks of chemotherapy was 6.13 ± 0.49, at 6-10 weeks (6.32 ± 0.51), and at 11-15 weeks (7.12 ± 0.36). The mean skin pH of patients with two drugs (5.98 ± 0.44), four drugs (6.28 ± 0.55), and six drugs (6.63 ± 0.56).
The highest mean of skin pH were obtained in AML group, 11-15 weeks length of chemotherapy and group with six drugs regimen.
白血病的治疗方法之一是化疗。这种治疗的副作用和毒性可出现在皮肤、附属器和黏膜上。它们可能会增加皮肤表面的潜在氢离子(pH)值,从而破坏表皮屏障防御功能。
描述接受化疗的白血病患儿的皮肤pH值。
本研究为观察性描述性横断面研究,于2016年3月至12月进行,以棉兰哈芝·亚当·马利克综合医院治疗的32例白血病患儿为研究对象。用pH计测量皮肤pH值。
我们发现急性淋巴细胞白血病(ALL)的平均皮肤pH值为(6.28±0.58),慢性粒细胞白血病(CML)为(5.9±0),急性髓系白血病(AML)为(6.5±0.50)。化疗1 - 5周后的平均皮肤pH值为6.13±0.49,6 - 10周为(6.32±0.51),11 - 15周为(7.12±0.36)。使用两种药物的患者平均皮肤pH值为(5.98±0.44),四种药物为(6.28±0.55),六种药物为(6.63±0.56)。
AML组、化疗11 - 15周以及采用六种药物方案的组皮肤pH值均值最高。