儿童急性髓细胞白血病的流行病学。
Epidemiology of childhood acute myeloid leukemia.
机构信息
Center for Health Outcomes and Prevention Research, Sanford Research, Sioux Falls, South Dakota 57104, USA.
出版信息
Pediatr Blood Cancer. 2013 May;60(5):728-33. doi: 10.1002/pbc.24464. Epub 2013 Jan 9.
Abstract
Although leukemia is the most common childhood cancer diagnosis, the subtype, acute myeloid leukemia (AML), is less common and fewer etiologic studies exist. This review summarizes the major risk factors for AML. We searched the literature using PubMed for articles on childhood AML and reviewed 180 articles. While few risk factors are definitive, we identified several with consistent evidence of a possible effect. Thorough analysis of genetic and epigenetic factors is missing from this literature and methodological issues are unresolved. Future studies should more closely examine causal mechanisms, improve exposure measurement, and include analysis using genetic and epigenetic factors.
摘要
虽然白血病是最常见的儿童癌症诊断，但亚型急性髓细胞白血病 (AML) 则较为少见，且相关病因研究较少。本综述总结了 AML 的主要危险因素。我们使用 PubMed 搜索了有关儿童 AML 的文献，并回顾了 180 篇文章。虽然很少有危险因素是确定的，但我们发现了一些具有可能影响的一致证据。该文献中缺乏对遗传和表观遗传因素的深入分析，方法学问题也未得到解决。未来的研究应更仔细地研究因果机制，改进暴露测量，并包括使用遗传和表观遗传因素的分析。
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