Lestari Indah Nur, Yoel Chairul, Lubis Munar
Department of Child Health, Medical School, University of Sumatera Utara, Medan, Indonesia.
Open Access Maced J Med Sci. 2019 Mar 26;7(6):959-961. doi: 10.3889/oamjms.2019.211. eCollection 2019 Mar 30.
Sepsis is a significant cause of morbidity and mortality in children. The diagnosis of sepsis remains continuing to develop which determines treatment and prognostic. Antithrombin III is one of the coagulation markers to evaluate the prognosis of sepsis.
To determine the association between the level of antithrombin III and mortality in children with sepsis in the Pediatric Intensive Care Unit, Haji Adam Malik General Hospital, Medan.
A cross-sectional study was conducted in Haji Adam Malik General Hospital, Medan from April until June 2015. There were 41 children with sepsis. Sepsis was diagnosed from clinical and laboratory findings. Complete blood count, antithrombin III level, C-reactive protein and procalcitonin were an indicator of unproven sepsis that performed in the laboratory. Meanwhile blood culture was performed in the microbiology laboratory. The association between the level of antithrombin III and mortality was analysed by using chi-square test.
Of the 41 participants, the low antithrombin III level was 13 of 41 children (31.7%) meanwhile the normal antithrombin III level was 28 of 41 children (68.3%). There was 8 of 13 (42.1%) and 11 of 28 (57.9%) children in death cases of low and normal antithrombin III level, respectively. Samples with low antithrombin III level had 2.473 higher risk mortality than normal antithrombin III level (P = 0.184; 95% CI 0.641 to 9.5421; PR = 2.473).
There was no statistically significant association between levels of antithrombin III and mortality in children with sepsis.
脓毒症是儿童发病和死亡的重要原因。脓毒症的诊断仍在不断发展，这决定了治疗和预后。抗凝血酶III是评估脓毒症预后的凝血标志物之一。
确定棉兰市哈贾·亚当·马利克综合医院儿科重症监护病房脓毒症患儿抗凝血酶III水平与死亡率之间的关联。
2015年4月至6月在棉兰市哈贾·亚当·马利克综合医院进行了一项横断面研究。有41例脓毒症患儿。脓毒症根据临床和实验室检查结果诊断。全血细胞计数、抗凝血酶III水平、C反应蛋白和降钙素原是实验室进行的未经验证的脓毒症指标。同时在微生物实验室进行血培养。采用卡方检验分析抗凝血酶III水平与死亡率之间的关联。
41名参与者中，抗凝血酶III水平低的有13名儿童（31.7%），抗凝血酶III水平正常的有28名儿童（68.3%）。抗凝血酶III水平低和正常的死亡病例中分别有8名（42.1%）和11名（57.9%）儿童。抗凝血酶III水平低的样本死亡风险比抗凝血酶III水平正常的样本高2.473倍（P = 0.184；95% CI 0.641至9.5421；PR = 2.473）。
脓毒症患儿抗凝血酶III水平与死亡率之间无统计学显著关联。
