印度尼西亚棉兰哈芝亚当马利克综合医院糖尿病患者中影响 COVID-19 结局的因素
Factors Affecting the Outcomes of COVID-19 in Diabetes Patients at Haji Adam Malik General Hospital Medan, Indonesia.
作者信息
Marpaung Nadya Joana, Lubis Mustafa Ali Azmi, Amelia Rina
机构信息
Undergraduated Program in Medicine, Faculty of Medicine, Universitas Sumatera Utara, Medan. Indonesia.
Department of Community Medicine, Faculty of Medicine, Universitas Sumatera Utara, Medan. Indonesia.
出版信息
Acta Inform Med. 2023;31(3):182-185. doi: 10.5455/aim.2023.31.182-185.
BACKGROUND
COVID-19 is a virulent viral infection by SARS-CoV-2 which caused pandemic and high mortality. One of the numerous risk factors for worse clinical outcomes in COVID-19 patients is the presence of comorbidity. Diabetes Mellitus is a chronic metabolic disease frequently in COVID-19 patients. Insulin resistance, causes chronic inflammation in the body, may aggravate the clinical outcome COVID-19 patients.
OBJECTIVE
The aim of the study was to examine factors that impact clinical outcomes in COVID-19 T2DM patients.
METHODS
The method used an analytical method with cross sectional design. Population is inpatients in Haji Adam Malik Hospital diagnosed with COVID-19 and Diabetes Mellitus Type 2 with 99 inpatients as sample. The data used are secondary data obtained through medical records from a hospital covering patients characteristics and laboratory result The data was analyzed using t-independent and chi square test with SPSS program.
RESULTS
Clinical outcomes for 99 patients are 60 patients are cured and 39 patients are dead. analytical study found a significant correlation between factors impacting clinical outcomes on COVID-19 patients with T2DM that are HbA1c level, D-dimer, cholesterol total and COVID-19 degree of severity and the clinical outcomes (p<0,05).
CONCLUSION
HbA1c level, D-dimer, total cholesterol and the infection degree of severity affects the clinical outcomes on COVID-19 with T2DM (p<0,05).
背景
新型冠状病毒肺炎（COVID-19）是由严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引起的一种致命性病毒感染，导致了大流行和高死亡率。COVID-19患者临床结局较差的众多风险因素之一是合并症的存在。糖尿病是COVID-19患者中常见的一种慢性代谢性疾病。胰岛素抵抗会导致体内慢性炎症，可能会加重COVID-19患者的临床结局。
目的
本研究的目的是探讨影响COVID-19合并2型糖尿病（T2DM）患者临床结局的因素。
方法
该方法采用横断面设计的分析方法。研究对象为哈芝亚当·马利克医院诊断为COVID-19和2型糖尿病的住院患者，以99名住院患者为样本。所使用的数据是通过医院病历获得的二手数据，涵盖患者特征和实验室结果。使用SPSS程序进行独立样本t检验和卡方检验对数据进行分析。
结果
99例患者的临床结局为60例治愈，39例死亡。分析研究发现，影响COVID-19合并T2DM患者临床结局的因素，即糖化血红蛋白（HbA1c）水平、D-二聚体、总胆固醇和COVID-19严重程度与临床结局之间存在显著相关性（p<0.05）。
结论
HbA1c水平、D-二聚体、总胆固醇和感染严重程度影响COVID-19合并T2DM患者的临床结局（p<0.05）。
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